PROSITE documentation PDOC00979Glucokinase regulatory protein family signature
The glucokinase regulatory protein (GCKR) [1] is a vertebrate protein that inhibits glucokinase by forming a complex with the enzyme, which plays a role in the control of blood glucose homeostasis. GCKR is a protein of about 70 Kd which is evolutionary related to bacterial N-acetylmuramic acid 6-phosphate etherases (MurNAc-6-P etherase, murQ) which are about half the size of GCKR and form active homodimers. MurNAc-6-P etherases catalyze the cleavage of the D-lactyl ether substituent of the bacterial cell wall sugar MurNAc and play a role in recycling of the cell wall [2]. The 3D structure of the Haemophilus influenzae HI0754/murQ protein (see <PDB:1NRI>) shows structural relationships with other sugar isomerase (SIS) domain proteins (see <PDOC51464>). In contrast to mono-SIS bacterial MurNAc-6-P etherase, mammalian GCKR is composed of two SIS domains.
As a signature pattern, we selected one of at least four well conserved regions found in those proteins.
Last update:September 2009 / Text revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Veiga-Da-Cunha M. Detheux M. Watelet N. Van Schaftingen E. |
| Title | Cloning and expression of a Xenopus liver cDNA encoding a fructose-phosphate-insensitive regulatory protein of glucokinase. | |
| Source | Eur. J. Biochem. 225:43-51(1994). | |
| PubMed ID | 7925465 |
| 2 | Authors | Jaeger T. Mayer C. |
| Title | N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism. | |
| Source | Cell. Mol. Life Sci. 65:928-939(2008). | |
| PubMed ID | 18049859 | |
| DOI | 10.1007/s00018-007-7399- |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)