PROSITE documentation PDOC00993NAD:arginine ADP-ribosyltransferase signature
Mono(ADP-ribosyl)transferase (EC 2.4.2.31) catalyzes the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD) to an acceptor amino acid in proteins. In vertebrates there is a family of such enzymes that transfer an NAD group to arginine [1].
At least five distinct forms of this enzyme has been found so far, some are attached to the membrane by a GPI anchor while others seem to be secreted. They are proteins of about 250 to 300 amino acid residues. As a signature pattern, we selected a conserved region in the central section of these enzymes.
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Okazaki I.J. Kim H.-J. Moss J. |
| Title | Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. | |
| Source | J. Biol. Chem. 271:22052-22057(1996). | |
| PubMed ID | 8703012 |
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