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PROSITE documentation PDOC00993

NAD:arginine ADP-ribosyltransferase signature


Mono(ADP-ribosyl)transferase (EC catalyzes the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD) to an acceptor amino acid in proteins. In vertebrates there is a family of such enzymes that transfer an NAD group to arginine [1].

At least five distinct forms of this enzyme has been found so far, some are attached to the membrane by a GPI anchor while others seem to be secreted. They are proteins of about 250 to 300 amino acid residues. As a signature pattern, we selected a conserved region in the central section of these enzymes.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

ART, PS01291; NAD:arginine ADP-ribosyltransferases signature  (PATTERN)


1AuthorsOkazaki I.J. Kim H.-J. Moss J.
TitleCloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase.
SourceJ. Biol. Chem. 271:22052-22057(1996).
PubMed ID8703012

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