PROSITE documentation PDOC00997
4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature


The bacterial ispD protein [1] catalyzes the third step of the deoxyxylulose-5-phosphate pathway (DXP) of isoprenoid biosynthesis; the formation of 4-diphosphocytidyl-2C-methyl-D-erythritol from CTP and 2C-methyl-D-erythritol 4-phosphate.

These proteins can be picked up in the database by a pattern centered on a central conserved region that contains a conserved Asp and Arg residues.

Last update:

December 2001 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ISPD, PS01295; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature  (PATTERN)


1AuthorsRohdich F. Wungsintaweekul J. Fellermeier M. Sagner S. Herz S. Kis K. Eisenreich W. Bacher A. Zenk M.H.
TitleCytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.
SourceProc. Natl. Acad. Sci. U.S.A. 96:11758-11763(1999).
PubMed ID10518523

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