PROSITE documentation PDOC00998
RsmI AdoMet-dependent methyltransferase protein family signature


In bacterial 16S rRNAs, methylated nucleosides are clustered within the decoding center, and these nucleoside modifications are thought to modulate translational fidelity. The N(4), 2'-O-dimethylcytidine (m(4)Cm) at position 1402 of the Escherichia coli 16S rRNA directly interacts with the P-site codon of the mRNA. RsmI is an AdoMet-dependent methyltransferase responsible for the 2'O-methylation of C1402. It is conserved in almost all species of bacteria [1].

Proteins of the RsmI family are of about 30 to 34 Kd and contain a number of conserved regions. As a signature pattern, we selected a highly conserved region in their central section.

Last update:

April 2010 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RSMI, PS01296; RsmI AdoMet-dependent methyltransferase protein family signature  (PATTERN)


1AuthorsKimura S. Suzuki T.
TitleFine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA.
SourceNucleic Acids Res. 38:1341-1352(2010).
PubMed ID19965768

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