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| PROSITE documentation PDOC00998 |
RsmI AdoMet-dependent methyltransferase protein family signature
In bacterial 16S rRNAs, methylated nucleosides are clustered within the decoding center, and these nucleoside modifications are thought to modulate translational fidelity. The N(4), 2'-O-dimethylcytidine (m(4)Cm) at position 1402 of the Escherichia coli 16S rRNA directly interacts with the P-site codon of the mRNA. RsmI is an AdoMet-dependent methyltransferase responsible for the 2'O-methylation of C1402. It is conserved in almost all species of bacteria [1].
Proteins of the RsmI family are of about 30 to 34 Kd and contain a number of conserved regions. As a signature pattern, we selected a highly conserved region in their central section.
Last update:April 2010 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Kimura S. Suzuki T. |
| Title | Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA. | |
| Source | Nucleic Acids Res. 38:1341-1352(2010). | |
| PubMed ID | 19965768 | |
| DOI | 10.1093/nar/gkp1073 |
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