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| PROSITE documentation PDOC01007 |
BCCT family of transporters signature
The following prokaryotic transport proteins are evolutionary related [1]:
- Escherichia coli high-affinity choline transport protein betT.
- Escherichia coli carnitine transport protein caiT.
- Bacillis subtilis glycine βine transporter opuD.
- Corynebacterium glutamicum glycine βine transporter betP.
- Escherichia coli hypothetical protein yeaV.
- Haemophilus influenzae hypothetical protein HI1706.
- Mycobacterium tuberculosis hypothetical protein MtCY21C12.11.
These transport proteins belong to a family known as BCCT (for βine / Carnitine / Choline Transporters) which are specific for compounds containing a quaternary nitrogen atom. These proteins contains 12 transmembrane regions and are energized by proton symport. They contains a concerved region with 4 tryptophans in their central region. We use this region as a signature pattern.
Note:These proteins belongs to family TC 2.33 in the classification of transporters [2].
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Kappes R.M. Kempf B. Bremer E. |
| Title | Three transport systems for the osmoprotectant glycine betaine operate in Bacillus subtilis: characterization of OpuD. | |
| Source | J. Bacteriol. 178:5071-5079(1996). | |
| PubMed ID | 8752321 |
| 2 | Authors | Saier M.H. Jr. |
| Source | Adv. Microbiol. Physiol. 40:81-136(1998). |
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