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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE documentation PDOC01007
BCCT family of transporters signature


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PURL: https://purl.expasy.org/prosite/documentation/PDOC01007

Description

The following prokaryotic transport proteins are evolutionary related [1]:

  • Escherichia coli high-affinity choline transport protein betT.
  • Escherichia coli carnitine transport protein caiT.
  • Bacillis subtilis glycine βine transporter opuD.
  • Corynebacterium glutamicum glycine βine transporter betP.
  • Escherichia coli hypothetical protein yeaV.
  • Haemophilus influenzae hypothetical protein HI1706.
  • Mycobacterium tuberculosis hypothetical protein MtCY21C12.11.

These transport proteins belong to a family known as BCCT (for βine / Carnitine / Choline Transporters) which are specific for compounds containing a quaternary nitrogen atom. These proteins contains 12 transmembrane regions and are energized by proton symport. They contains a concerved region with 4 tryptophans in their central region. We use this region as a signature pattern.

Note:

These proteins belongs to family TC 2.33 in the classification of transporters [2].

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

BCCT, PS01303; BCCT family of transporters signature  (PATTERN)


References

1AuthorsKappes R.M. Kempf B. Bremer E.
TitleThree transport systems for the osmoprotectant glycine betaine operate in Bacillus subtilis: characterization of OpuD.
SourceJ. Bacteriol. 178:5071-5079(1996).
PubMed ID8752321

2AuthorsSaier M.H. Jr.
SourceAdv. Microbiol. Physiol. 40:81-136(1998).



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