PROSITE documentation PDOC01007
BCCT family of transporters signature


The following prokaryotic transport proteins are evolutionary related [1]:

  • Escherichia coli high-affinity choline transport protein betT.
  • Escherichia coli carnitine transport protein caiT.
  • Bacillis subtilis glycine βine transporter opuD.
  • Corynebacterium glutamicum glycine βine transporter betP.
  • Escherichia coli hypothetical protein yeaV.
  • Haemophilus influenzae hypothetical protein HI1706.
  • Mycobacterium tuberculosis hypothetical protein MtCY21C12.11.

These transport proteins belong to a family known as BCCT (for βine / Carnitine / Choline Transporters) which are specific for compounds containing a quaternary nitrogen atom. These proteins contains 12 transmembrane regions and are energized by proton symport. They contains a concerved region with 4 tryptophans in their central region. We use this region as a signature pattern.


These proteins belongs to family TC 2.33 in the classification of transporters [2].

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

BCCT, PS01303; BCCT family of transporters signature  (PATTERN)


1AuthorsKappes R.M. Kempf B. Bremer E.
TitleThree transport systems for the osmoprotectant glycine betaine operate in Bacillus subtilis: characterization of OpuD.
SourceJ. Bacteriol. 178:5071-5079(1996).
PubMed ID8752321

2AuthorsSaier M.H. Jr.
SourceAdv. Microbiol. Physiol. 40:81-136(1998).

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