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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE documentation PDOC01034
Thymidylate kinase signature


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PURL: https://purl.expasy.org/prosite/documentation/PDOC01034

Description

Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium. This enzyme is important in the pathway of synthesis of dTTP from dTMP. Thymidylate kinase is an ubiquitous enzyme of about 25 Kd.

As a signature pattern, we selected a region located in the central section of these proteins.

Note:

Proteins belonging to this family also contain a copy of the ATP/GTP- binding motif 'A' (P-loop) in their N-terminal extremity (see <PDOC00017>).

Last update:

December 2001 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

THYMIDYLATE_KINASE, PS01331; Thymidylate kinase signature  (PATTERN)


Reference



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