PROSITE documentation PDOC01037Methylglyoxal synthase active site
Description
Methylglyoxal synthase (EC 4.2.3.3) (MGS) [1] catalyzes the conversion of dihydroxyacetone phosphate to methylglyoxal and phosphate. It provides bacteria with an alternative to triosephosphate isomerase for metabolizing dihydroxyacetone phosphate.
MGS is a small protein of about 13 to 17 kD. An aspartate residue is involved in the catalytic mechanism. We developed a signature pattern that includes that residue.
Last update:April 2006 / Pattern revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Saadat D. Harrison D.H.T. |
| Title | The crystal structure of methylglyoxal synthase from Escherichia coli. | |
| Source | Structure 7:309-317(1999). | |
| PubMed ID | 10368300 |
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