PROSITE documentation PDOC01054Short hematopoietin receptor family 2 signature
A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [1,2] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.
One subset of individual receptor chains that are part of receptor complexes for small hematopoietins contain common structural elements in their extracellular parts: an immunoglobulin-like domain at the N-terminal end of the hematopoietin receptor domain and a rather short cytoplasmic domain. They define a structural subgroup containing the following chains:
- Granulocyte/macrophage colony stimulating factor receptor α (GMCSFRA).
- Interleukin-3 receptor α chain (IL3RA).
- Interleukin-5 receptor α chain (IL5RA).
- Interleukin-13 receptor α-1 chain (IL13RA1).
- Interleukin-13 receptor α-2 chain (IL13RA2).
A schematic representation of the structure of these receptors is shown below:
+-----------+-------------------------------------------xxxxxxx-------------+ | Ig-like | C C C C Extracellular XXXXXXX Cytoplasmic | +-----------+--|-|-----|--|-----------------------------xxxxxxx-------------+ | | | | Transmembrane +-+ +--+
GMCSFRA, IL3RA or IL5RA chains of this subgroup bind to their cognate cytokines: GM-CSF, IL-3 and IL-5, with a common β chain, KH97/AIC2B [3].
Either IL13RA1 chain or IL13RA2 chain form the IL13R complex together with IL4RA chain. IL-4 can compete with IL-13 to bind to either IL13R form [4].
We have used one pattern to detect this subfamily. The motif is located a the N-terminal end of the 200 amino acid hematopoietin domain.
Expert(s) to contact by email: Last update:December 2001 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Boulay J.-L. Paul W.E. |
Title | Hematopoietin sub-family classification based on size, gene organization and sequence homology. | |
Source | Curr. Biol. 3:573-581(1993). | |
PubMed ID | 15335670 |
2 | Authors | Sprang S.R. Bazan J.F. |
Source | Curr. Opin. Struct. Biol. 3:815-827(1993). |
3 | Authors | Nicola N.A. Metcalf D. |
Title | Subunit promiscuity among hemopoietic growth factor receptors. | |
Source | Cell 67:1-4(1991). | |
PubMed ID | 1913811 |
4 | Authors | Hilton D.J. Zhang J.G. Metcalf D. Alexander W.S. Nicola N.A. Willson T.A. |
Title | Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. | |
Source | Proc. Natl. Acad. Sci. U.S.A. 93:497-501(1996). | |
PubMed ID | 8552669 |
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