PROSITE documentation PDOC01054
Short hematopoietin receptor family 2 signature


A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [1,2] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.

One subset of individual receptor chains that are part of receptor complexes for small hematopoietins contain common structural elements in their extracellular parts: an immunoglobulin-like domain at the N-terminal end of the hematopoietin receptor domain and a rather short cytoplasmic domain. They define a structural subgroup containing the following chains:

  • Granulocyte/macrophage colony stimulating factor receptor α (GMCSFRA).
  • Interleukin-3 receptor α chain (IL3RA).
  • Interleukin-5 receptor α chain (IL5RA).
  • Interleukin-13 receptor α-1 chain (IL13RA1).
  • Interleukin-13 receptor α-2 chain (IL13RA2).

A schematic representation of the structure of these receptors is shown below:

 |  Ig-like  |  C C     C  C         Extracellular       XXXXXXX Cytoplasmic |
                | |     |  |                          Transmembrane
                +-+     +--+

GMCSFRA, IL3RA or IL5RA chains of this subgroup bind to their cognate cytokines: GM-CSF, IL-3 and IL-5, with a common β chain, KH97/AIC2B [3].

Either IL13RA1 chain or IL13RA2 chain form the IL13R complex together with IL4RA chain. IL-4 can compete with IL-13 to bind to either IL13R form [4].

We have used one pattern to detect this subfamily. The motif is located a the N-terminal end of the 200 amino acid hematopoietin domain.

Expert(s) to contact by email:

Boulay J.-L.

Last update:

December 2001 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HEMATOPO_REC_S_F2, PS01356; Short hematopoietin receptor family 2 signature  (PATTERN)


1AuthorsBoulay J.-L. Paul W.E.
TitleHematopoietin sub-family classification based on size, gene organization and sequence homology.
SourceCurr. Biol. 3:573-581(1993).
PubMed ID15335670

2AuthorsSprang S.R. Bazan J.F.
SourceCurr. Opin. Struct. Biol. 3:815-827(1993).

3AuthorsNicola N.A. Metcalf D.
TitleSubunit promiscuity among hemopoietic growth factor receptors.
SourceCell 67:1-4(1991).
PubMed ID1913811

4AuthorsHilton D.J. Zhang J.G. Metcalf D. Alexander W.S. Nicola N.A. Willson T.A.
TitleCloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.
SourceProc. Natl. Acad. Sci. U.S.A. 93:497-501(1996).
PubMed ID8552669

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