PROSITE documentation PDOC50077HEAT repeat profile
The HEAT repeat is a tandemly repeated, 37-47 amino acids long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd α regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1 [1]. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes.
In the crystal structure of PP2A PR65/A [2], the HEAT repeats consist of pairs of antiparallel α helices.
Last update:December 2001 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Andrade M.A. Bork P. |
| Title | HEAT repeats in the Huntington's disease protein. | |
| Source | Nat. Genet. 11:115-116(1995). | |
| PubMed ID | 7550332 | |
| DOI | 10.1038/ng1095-115 |
| 2 | Authors | Groves M.R. Hanlon N. Turowski P. Hemmings B.A. Barford D. |
| Title | The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. | |
| Source | Cell 96:99-110(1999). | |
| PubMed ID | 9989501 |
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