PROSITE documentation PDOC50077

HEAT repeat profile


The HEAT repeat is a tandemly repeated, 37-47 amino acids long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd α regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1 [1]. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes.

In the crystal structure of PP2A PR65/A [2], the HEAT repeats consist of pairs of antiparallel α helices.

Last update:

December 2001 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

HEAT_REPEAT, PS50077; HEAT repeat profile  (MATRIX)


1AuthorsAndrade M.A., Bork P.
TitleHEAT repeats in the Huntington's disease protein.
SourceNat. Genet. 11:115-116(1995).
PubMed ID7550332

2AuthorsGroves M.R., Hanlon N., Turowski P., Hemmings B.A., Barford D.
TitleThe structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
SourceCell 96:99-110(1999).
PubMed ID9989501

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