|PROSITE documentation PDOC50077|
The HEAT repeat is a tandemly repeated, 37-47 amino acids long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd α regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1 . Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes.
In the crystal structure of PP2A PR65/A , the HEAT repeats consist of pairs of antiparallel α helices.Last update:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Andrade M.A., Bork P.|
|Title||HEAT repeats in the Huntington's disease protein.|
|Source||Nat. Genet. 11:115-116(1995).|
|2||Authors||Groves M.R., Hanlon N., Turowski P., Hemmings B.A., Barford D.|
|Title||The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.|