PROSITE documentation PDOC50145Zinc finger TRAF-type profile
TRAF proteins were isolated first by their ability to interact with TNF receptor [1]. They are involved in different cytoplasmic signal transduction pathways. TRAF proteins are composed of 3 structural domains: a RING finger (see <PDOC00449>) in the N terminal part of the protein, TRAF zinc fingers in the middle part and the TRAF domain in the C terminal part. TRAF zinc fingers contain 8 possible ligands for one or two zinc atoms. This domain is found only in TRAF and TRAF-related proteins and its function is not yet known.
The profile we developed covers the whole domain.
Last update:January 2002 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Rothe M. Wong S.C. Henzel W.J. Goeddel D.V. |
| Title | A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. | |
| Source | Cell 78:681-692(1994). | |
| PubMed ID | 8069916 |
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