We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC50165UvrC family homology region profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC50165
Description
In prokaryote, nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC protein complex [1].
UvrC proteins contain 4 conserved regions: the UVR domain which interacts with uvrB (see <PDOC50151>), a Helix hairpin Helix (HhH) domain important for 5 prime incision of damage DNA, the GIY-YIG domain (see <PDOC50164>) and a central homology region of unknown function, which is specific for UvrC proteins.
Last update:May 2012 / New text.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Van Houten B. Snowden A. |
| Source | BioEssays 15:51-59(1993). |
| 2 | Authors | Sancar A. |
| Title | DNA excision repair. | |
| Source | Annu. Rev. Biochem. 65:43-81(1996). | |
| PubMed ID | 8811174 | |
| DOI | 10.1146/annurev.bi.65.070196.000355 |
Copyright
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