PROSITE documentation PDOC50165UvrC family homology region profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC50165
Description
In prokaryote, nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC protein complex [1].
UvrC proteins contain 4 conserved regions: the UVR domain which interacts with uvrB (see <PDOC50151>), a Helix hairpin Helix (HhH) domain important for 5 prime incision of damage DNA, the GIY-YIG domain (see <PDOC50164>) and a central homology region of unknown function, which is specific for UvrC proteins.
Last update:May 2012 / New text.
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References
| 1 | Authors | Van Houten B. Snowden A. |
| Source | BioEssays 15:51-59(1993). |
| 2 | Authors | Sancar A. |
| Title | DNA excision repair. | |
| Source | Annu. Rev. Biochem. 65:43-81(1996). | |
| PubMed ID | 8811174 | |
| DOI | 10.1146/annurev.bi.65.070196.000355 |
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