PROSITE documentation PDOC50165UvrC family homology region profile
Description
In prokaryote, nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC protein complex [1].
UvrC proteins contain 4 conserved regions: the UVR domain which interacts with uvrB (see <PDOC50151>), a Helix hairpin Helix (HhH) domain important for 5 prime incision of damage DNA, the GIY-YIG domain (see <PDOC50164>) and a central homology region of unknown function, which is specific for UvrC proteins.
Last update:May 2012 / New text.
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References
| 1 | Authors | Van Houten B. Snowden A. |
| Source | BioEssays 15:51-59(1993). |
| 2 | Authors | Sancar A. |
| Title | DNA excision repair. | |
| Source | Annu. Rev. Biochem. 65:43-81(1996). | |
| PubMed ID | 8811174 | |
| DOI | 10.1146/annurev.bi.65.070196.000355 |
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