PROSITE documentation PDOC50173
UmuC domain profile


In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins umuC, umuD and recA. This machinery allow the replication to continue through DNA lesion, and therefore avoid lethal interruption of DNA replication after DNA damage [1].

Proteins known to contain an UmuC domain are listed below:

  • Bacterial umuC protein.
  • Escherichia coli mucB and Salmonella typhimurium impB proteins. Plasmid- born analogues of the UmuC protein.
  • Salmonella typhimurium samB, a plasmid associated homologue of UmuC .
  • Bacterial DNA polymerase IV.
  • Yeast REV1 protein, required for normal induction of mutations by physical and chemical agents.

The profile we developed spans the complete UmuC domain.

Last update:

September 2002 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

UMUC, PS50173; UmuC domain profile  (MATRIX)


1AuthorsSmith B.T. Walker G.C.
TitleMutagenesis and more: umuDC and the Escherichia coli SOS response.
SourceGenetics 148:1599-1610(1998).
PubMed ID9560379

2AuthorsWalker G.C.
TitleSOS-regulated proteins in translesion DNA synthesis and mutagenesis.
SourceTrends Biochem. Sci. 20:416-420(1995).
PubMed ID8533155

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