We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC50173UmuC domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC50173
Description
In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins umuC, umuD and recA. This machinery allow the replication to continue through DNA lesion, and therefore avoid lethal interruption of DNA replication after DNA damage [1].
Proteins known to contain an UmuC domain are listed below:
- Bacterial umuC protein.
- Escherichia coli mucB and Salmonella typhimurium impB proteins. Plasmid- born analogues of the UmuC protein.
- Salmonella typhimurium samB, a plasmid associated homologue of UmuC .
- Bacterial DNA polymerase IV.
- Yeast REV1 protein, required for normal induction of mutations by physical and chemical agents.
The profile we developed spans the complete UmuC domain.
Last update:September 2002 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Smith B.T. Walker G.C. |
| Title | Mutagenesis and more: umuDC and the Escherichia coli SOS response. | |
| Source | Genetics 148:1599-1610(1998). | |
| PubMed ID | 9560379 |
| 2 | Authors | Walker G.C. |
| Title | SOS-regulated proteins in translesion DNA synthesis and mutagenesis. | |
| Source | Trends Biochem. Sci. 20:416-420(1995). | |
| PubMed ID | 8533155 |
Copyright
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