![]() |
|
PROSITE documentation PDOC50271 |
The UBP-type zinc finger was first isolated in some members of a subfamily of deubiquitinating enzyme, the ubiquitin-specific processing protease (UBP) (see <PDOC00750>). HDAC6 UBP-type zinc finger has been shown to interact with ubiquitin [1,2]. Like with other ubiquitin binding domain (UBD) the interaction with ubiquitin is moderate or even weak. In addition, several UBD families have members that do not interact with ubiquitin at all, which emphasis that binding domains that are identified by similarity searches should be experimentally verified [3].
Some proteins containing an UBP-type zinc finger are listed below:
The profile we developed covers the whole UBP-type zinc finger.
Note:The UBP-type zinc finger is also known as the PAZ domain, but this name describes another domain in the literature (see <PDOC50821>).
Last update:October 2005 / First entry.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Seigneurin-Berny D. Verdel A. Curtet S. Lemercier C. Garin J. Rousseaux S. Khochbin S. |
Title | Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. | |
Source | Mol. Cell. Biol. 21:8035-8044(2001). | |
PubMed ID | 11689694 | |
DOI | 10.1128/MCB.21.23.8035-8044.2001 |
2 | Authors | Hook S.S. Orian A. Cowley S.M. Eisenman R.N. |
Title | Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. | |
Source | Proc. Natl. Acad. Sci. U.S.A. 99:13425-13430(2002). | |
PubMed ID | 12354939 | |
DOI | 10.1073/pnas.172511699 |
3 | Authors | Hicke L. Schubert H.L. Hill C.P. |
Title | Ubiquitin-binding domains. | |
Source | Nat. Rev. Mol. Cell Biol. 6:610-621(2005). | |
PubMed ID | 16064137 | |
DOI | 10.1038/nrm1701 |