PROSITE documentation PDOC50845
Reticulon domain profile


Eukaryotic proteins of the reticulon (RTN) family all share an association with the endoplasmic reticulum (ER). Whereas amino-terminal regions are not related to one another, all reticulon proteins share a 200-amino-acid residue region of sequence similarity at the C-terminus. This region contains two large hydrophobic regions separated by a 66-residue hydrophilic segment. The conserved hydrophobic C-terminal portion has been shown to play an essential role in the association of reticulons with the ER membrane. The hydrophobic portions are supposed to be membrane-embedded and the hydrophilic 66-residue localized to the lumenal/extracellular face of the membrane. Most reticulons have a di-lysine ER retention motif at the C-terminus. Because of their likely association with the rough as well as the smooth ER, the reticulons might play some role in transport processes or in regulation of intracellular calcium levels. It has been suggested that the reticulons may be serving as ER-associated channel-like complexes [1,2,3,4,5].

The profile we developed covers the entire conserved C-terminal reticulon domain.

Last update:

January 2002 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RETICULON, PS50845; Reticulon domain profile  (MATRIX)


1Authorsvan de Velde H.J.K. Roebroek A.J.M. Senden N.H.M. Ramaekers F.C.S. Van de Ven W.J.M.
SourceJ. Cell Sci. 107:2403-2416(1994).

2AuthorsRoebroek A.J.M. Ayoubi T.A.Y. van de Velde H.J.K. Schoenmakers E.F.P.M. Pauli I.G.L. Van de Ven W.J.M.
TitleGenomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons.
SourceGenomics 32:191-199(1996).
PubMed ID8833145

3AuthorsRoebroek A.J.M. Contreras B. Pauli I.G.L. Van de Ven W.J.M.
TitlecDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons.
SourceGenomics 51:98-106(1998).
PubMed ID9693037

4AuthorsMoreira E.F. Jaworski C.J. Rodriguez I.R.
TitleCloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13.
SourceGenomics 58:73-81(1999).
PubMed ID10331947

5AuthorsGrandPre T. Nakamura F. Vartanian T. Strittmatter S.M.
TitleIdentification of the Nogo inhibitor of axon regeneration as a Reticulon protein.
SourceNature 403:439-444(2000).
PubMed ID10667797

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