PROSITE documentation PDOC50901
FtsK domain profile


The FtsK domain is a hydrophilic domain of about 200 residues, which is found in:

  • Bacterial cell division protein ftsK (known as sporulation protein SpoIIIE in Bacillus subtilis).
  • A set of conjugative plasmid- and conjugative transposon-encoded proteins, generally called Tra proteins. These proteins come from an extremly wide range of species, including Gram-positive and Gram-negative bacilli and cocci, Streptomyces species, Agrobacterium spp., and archaebacteria. In cases in which a function is known, the protein is required for intercellular DNA transfer.

The FtsK domain contains a highly conserved putative ATP-binding P-loop motif (see <PDOC00017>) and is assumed to be cytoplasmic. It can be found in one to three copies and is thought to be involved in DNA translocation by coupling ATP hydrolysis to movement relative to the long axis of DNA [1,2,3].

The profile we developed covers the entire FtsK domain.

Last update:

August 2003 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

FTSK, PS50901; FtsK domain profile  (MATRIX)


1AuthorsBegg K.J. Dewar S.J. Donachie W.D.
TitleA new Escherichia coli cell division gene, ftsK.
SourceJ. Bacteriol. 177:6211-6222(1995).
PubMed ID7592387

2AuthorsErrington J. Bath J. Wu L.J.
TitleDNA transport in bacteria.
SourceNat. Rev. Mol. Cell Biol. 2:538-545(2001).
PubMed ID11433368

3AuthorsPallen M.J.
TitleThe ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?
SourceTrends Microbiol. 10:209-212(2002).
PubMed ID11973144

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