PROSITE documentation PDOC50901FtsK domain profile
Description
The FtsK domain is a hydrophilic domain of about 200 residues, which is found in:
- Bacterial cell division protein ftsK (known as sporulation protein SpoIIIE in Bacillus subtilis).
- A set of conjugative plasmid- and conjugative transposon-encoded proteins, generally called Tra proteins. These proteins come from an extremly wide range of species, including Gram-positive and Gram-negative bacilli and cocci, Streptomyces species, Agrobacterium spp., and archaebacteria. In cases in which a function is known, the protein is required for intercellular DNA transfer.
The FtsK domain contains a highly conserved putative ATP-binding P-loop motif (see <PDOC00017>) and is assumed to be cytoplasmic. It can be found in one to three copies and is thought to be involved in DNA translocation by coupling ATP hydrolysis to movement relative to the long axis of DNA [1,2,3].
The profile we developed covers the entire FtsK domain.
Last update:August 2003 / Text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Begg K.J. Dewar S.J. Donachie W.D. |
| Title | A new Escherichia coli cell division gene, ftsK. | |
| Source | J. Bacteriol. 177:6211-6222(1995). | |
| PubMed ID | 7592387 |
| 2 | Authors | Errington J. Bath J. Wu L.J. |
| Title | DNA transport in bacteria. | |
| Source | Nat. Rev. Mol. Cell Biol. 2:538-545(2001). | |
| PubMed ID | 11433368 | |
| DOI | 10.1038/35080005 |
| 3 | Authors | Pallen M.J. |
| Title | The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system? | |
| Source | Trends Microbiol. 10:209-212(2002). | |
| PubMed ID | 11973144 |
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