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PROSITE documentation PDOC50910 |
The HEPN (higher eukaryotes and prokaryotes nucleotide-binding) domain is a region of 110 residues found in the C-terminus of sacsin, a chaperonin implicated in an early-onset neurodegenerative disease in human, and in many bacterial and archaebacterial proteins. There are three classes of proteins with HEPN domain:
The crystal structure of the HEPN domain from the TM0613 protein of Thermotoga maritima indicates that it is structurally similar to the C-terminal all-α-helical domain of kanamycin nucleotidyltransferases (KNTases) (see <PDB:1O3U>). It is composed of five α helices, three of which form an up-and-down helical bundle, with a pair of short helices on the side. The distant structural similarity suggests that the HEPN domain might be involved in nucleotide binding [1].
The profile we developed covers the entire HEPN domain.
Last update:June 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Grynberg M. Erlandsen H. Godzik A. |
Title | HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. | |
Source | Trends Biochem. Sci. 28:224-226(2003). | |
PubMed ID | 12765831 |