PROSITE documentation PDOC50978NEAT domain profile
The NEAT (for 'near transporter') domain is a conserved region of about 125 amino acids, which appears in variable copy number (from one up to five) in bacterial genes that are usually in the vicinity of a putative Fe(3+) siderophore transporter. Most of the bacterial species containing this domain are pathogenic. The NEAT domain is found in combination with other domains, such as the LRR or the LPxTG motif (see <PDOC00373>). Given its predicted extracellular location and its close association with the components of an iron transport system, one possible function of the NEAT domain is to be a receptor of the siderophore-iron complex [1].
The predicted secondary structure of the NEAT domain suggests that this domain is mostly composed of β strands [1].
The profile we developed covers the entire NEAT domain.
Last update:April 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Andrade M.A. Ciccarelli F.D. Perez-Iratxeta C. Bork P. |
| Title | NEAT: a domain duplicated in genes near the components of a putative Fe3+ siderophore transporter from Gram-positive pathogenic bacteria. | |
| Source | Genome Biol. 3:RESEARCH0047-RESEARCH0047(2002). | |
| PubMed ID | 12225586 |
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