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PROSITE documentation PDOC50986 |
The MANSC (motif at N terminus with seven cysteines) domain is a module with a well-conserved seven cysteine motif that is present at the N terminus of higher multicellular animal membrane and extracellular proteins. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. Five classes of proteins contain single copies of the MANSC domain:
All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase [1].
The profile we developed covers the entire MANSC domain.
Last update:May 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Guo J. Chen S. Huang C. Chen L. Studholme D.J. Zhao S. Yu L. |
Title | MANSC: a seven-cysteine-containing domain present in animal membrane and extracellular proteins. | |
Source | Trends Biochem. Sci. 29:172-174(2004). | |
PubMed ID | 15124631 |