PROSITE documentation PDOC51016MyTH4 domain profile
The myosin tail homology 4 (MyTH4) domain is a ~150 amino acid module which has been identified in different branches of the myosin superfamily and in a microtubule motor protein from plants (kinesin-like calmodulin binding protein; KLCBP) [1]. The MyTH4 domain is found in one or two copies associated with other domains, such as myosin head, kinesin motor, FERM (see <PDOC00566>), PH (see <PDOC50003>), SH3 (see <PDOC50002>) and IQ (see <PDOC50096>). The function of the MyTH4 domain is presently unknown, although its presence in several different putative motor proteins raises the possibility that different motor proteins might share similar mechanisms for targeting or regulation [2].
The MyTH4 is predicted to be largely α-helical, interrupted by three or four turns. The MyTH4 domain contains four highly conserved regions designated MGD (consensus sequence L(K/R)(F/Y)MGDhP, LRDE (consensus LRDEhYCQhhKQHxxxN), RGW (consensus RGWxLh), and ELEA (RxxPPSxhELEA), where h indicates a hydrophobic residue and x is any residue [3].
The profile we developed covers the entire MyTH4 domain.
Last update:September 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Chen Z.-Y. Hasson T. Kelley P.M. Schwender B.J. Schwartz M.F. Ramakrishnan M. Kimberling W.J. Mooseker M.S. Corey D.P. |
| Title | Molecular cloning and domain structure of human myosin-VIIa, the gene product defective in Usher syndrome 1B. | |
| Source | Genomics 36:440-448(1996). | |
| PubMed ID | 8884267 |
| 2 | Authors | Oliver T.N. Berg J.S. Cheney R.E. |
| Title | Tails of unconventional myosins. | |
| Source | Cell. Mol. Life Sci. 56:243-257(1999). | |
| PubMed ID | 11212352 |
| 3 | Authors | Chen Z.-Y. Hasson T. Zhang D.-S. Schwender B.J. Derfler B.H. Mooseker M.S. Corey D.P. |
| Title | Myosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia. | |
| Source | Genomics 72:285-296(2001). | |
| PubMed ID | 11401444 | |
| DOI | 10.1006/geno.2000.6456 |
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