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PROSITE documentation PDOC51048 |
The SGT1-specific (SGS) domain is a module of ~90 amino acids, which was initially identified in eukaryotic SGT1 proteins [1]. It was latter also found in calcyclin-binding proteins [2]. The SGS domain has been shown to bind to proteins of the S100 family, which are thought to function as sensors of calcium ion concentration in the cell [2].
Some proteins known to contain a SGS domain are listed below:
The profile we developed covers the entire SGS domain.
Last update:December 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Azevedo C. Sadanandom A. Kitagawa K. Freialdenhoven A. Shirasu K. Schulze-Lefert P. |
Title | The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. | |
Source | Science 295:2073-2076(2002). | |
PubMed ID | 11847307 | |
DOI | 10.1126/science.1067554; |
2 | Authors | Nowotny M. Spiechowicz M. Jastrzebska B. Filipek A. Kitagawa K. Kuznicki J. |
Title | Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. | |
Source | J. Biol. Chem. 278:26923-26928(2003). | |
PubMed ID | 12746458 | |
DOI | 10.1074/jbc.M211518200; |