PROSITE documentation PDOC51048SGS domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51048
Description
The SGT1-specific (SGS) domain is a module of ~90 amino acids, which was initially identified in eukaryotic SGT1 proteins [1]. It was latter also found in calcyclin-binding proteins [2]. The SGS domain has been shown to bind to proteins of the S100 family, which are thought to function as sensors of calcium ion concentration in the cell [2].
Some proteins known to contain a SGS domain are listed below:
- Yeast suppressor of the G2 allele of skp1 (SGT1). It is required for cell cycle progression at the G1/S-phase and G2/M-phase transitions. It associates with Skp1 and regulates its function in the Skp1/Cullin1/F-box complex ubiquitin ligase and in kinetochore complexes.
- Arabidopsis thaliana SGT1a and SGT1b.
- Mammalian SGT1.
- Mammalian calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP), a component of a novel pathway of β-catenin ubiquitination.
The profile we developed covers the entire SGS domain.
Last update:December 2004 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Azevedo C. Sadanandom A. Kitagawa K. Freialdenhoven A. Shirasu K. Schulze-Lefert P. |
| Title | The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. | |
| Source | Science 295:2073-2076(2002). | |
| PubMed ID | 11847307 | |
| DOI | 10.1126/science.1067554; |
| 2 | Authors | Nowotny M. Spiechowicz M. Jastrzebska B. Filipek A. Kitagawa K. Kuznicki J. |
| Title | Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. | |
| Source | J. Biol. Chem. 278:26923-26928(2003). | |
| PubMed ID | 12746458 | |
| DOI | 10.1074/jbc.M211518200; |
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