PROSITE documentation PDOC51048

SGS domain profile


The SGT1-specific (SGS) domain is a module of ~90 amino acids, which was initially identified in eukaryotic SGT1 proteins [1]. It was latter also found in calcyclin-binding proteins [2]. The SGS domain has been shown to bind to proteins of the S100 family, which are thought to function as sensors of calcium ion concentration in the cell [2].

Some proteins known to contain a SGS domain are listed below:

  • Yeast suppressor of the G2 allele of skp1 (SGT1). It is required for cell cycle progression at the G1/S-phase and G2/M-phase transitions. It associates with Skp1 and regulates its function in the Skp1/Cullin1/F-box complex ubiquitin ligase and in kinetochore complexes.
  • Arabidopsis thaliana SGT1a and SGT1b.
  • Mammalian SGT1.
  • Mammalian calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP), a component of a novel pathway of β-catenin ubiquitination.

The profile we developed covers the entire SGS domain.

Last update:

December 2004 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

SGS, PS51048; SGS domain profile  (MATRIX)


1AuthorsAzevedo C., Sadanandom A., Kitagawa K., Freialdenhoven A., Shirasu K., Schulze-Lefert P.
TitleThe RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance.
SourceScience 295:2073-2076(2002).
PubMed ID11847307

2AuthorsNowotny M., Spiechowicz M., Jastrzebska B., Filipek A., Kitagawa K., Kuznicki J.
TitleCalcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins.
SourceJ. Biol. Chem. 278:26923-26928(2003).
PubMed ID12746458

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