|PROSITE documentation PDOC51132|
The olfactomedin-like or OLF domain is a module of ~260 residues present in metazoan secreted glycoproteins with a characteristic tissue-specific expression. The domain is named after bullfrog olfactomedin, an extracellular matrix protein of olfactory neuroepithelium, whereof it forms the C-terminal part. Other proteins of the olfactomedin family contain the OLF domain in the C-terminal part, while the N-terminus is more variable. Proteins of the latrophilin subfamily have an OLF domain in the N-terminal extracellular part, C-terminal to a SUEL-type lectin domain (see <PDOC50228>), and their C-terminal part contains domains of the G-protein coupled receptors family 2 (see <PDOC00559> and <PDOC50221>). Some OLF domain proteins are involved in the formation of the extracellular matrix, e.g. bullfrog olfactomedin, sea urchin amassin and C. elegans unc-122. In addition, OLF domain proteins can function in developmental processes, e.g. noelin and tiarin [1,2,3,4].
Secondary structure predictions show that the OLF domain contains several β-strands [2,3,4]. A disulfide bond between two conserved cysteines within the OLF domain of human myocilin is implicated in mutations associated with severe forms of primary open angle glaucoma .
Some proteins known to contain an olfactomedin-like domain:
The profile we developed covers the entire olfactomedin-like domain.Last update:
June 2005 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Torrado M. Trivedi R. Zinovieva R. Karavanova I. Tomarev S.I.|
|Title||Optimedin: a novel olfactomedin-related protein that interacts with myocilin.|
|Source||Hum. Mol. Genet. 11:1291-1301(2002).|
|2||Authors||Zhang J. Liu W.L. Tang D.C. Chen L. Wang M. Pack S.D. Zhuang Z. Rodgers G.P.|
|Title||Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development.|
|3||Authors||Nagy I. Trexler M. Patthy L.|
|Title||Expression and characterization of the olfactomedin domain of human myocilin.|
|Source||Biochem. Biophys. Res. Commun. 302:554-561(2003).|
|4||Authors||Zeng L.C. Liu F. Zhang X. Zhu Z.D. Wang Z.Q. Han Z.G. Ma W.J.|
|Title||hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis.|
|Source||FEBS Lett. 571:74-80(2004).|