PROSITE documentation PDOC51138EMSY N-terminal (ENT) domain profile
The EMSY N-terminal (ENT) domain is a ~90-residue module, which is unique in the human proteome, although multiple copies are found in Arabidopsis proteins. In the plant proteins, the ENT domains are accompanied by Agenet domains, plant specific homologues of Tudor domains (see <PDOC50304>) [1,2].
The ENT domain consists of a unique arrangement of five α-helices that fold into a helical bundle arrangement (see <PDB:1UZ3>). Overall, the three-dimensional structure adopts a club-like shape that consists of an extended N-terminal α-helix that connects to a helical bundle substructure. The ENT domain forms a homodimer via the anti-parallel packing of the long N-terminal α-helix from each subunit [3,4].
The profile we developed covers the entire ENT domain.
Last update:June 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Hughes-Davies L. Huntsman D. Ruas M. Fuks F. Bye J. Chin S.-F. Milner J. Brown L.A. Hsu F. Gilks B. Nielsen T. Schulzer M. Chia S. Ragaz J. Cahn A. Linger L. Ozdag H. Cattaneo E. Jordanova E.S. Schuuring E. Yu D.S. Venkitaraman A. Ponder B. Doherty A. Aparicio S. Bentley D. Theillet C. Ponting C.P. Caldas C. Kouzarides T. |
| Title | EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. | |
| Source | Cell 115:523-535(2003). | |
| PubMed ID | 14651845 |
| 2 | Authors | Maurer-Stroh S. Dickens N.J. Hughes-Davies L. Kouzarides T. Eisenhaber F. Ponting C.P. |
| Title | The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. | |
| Source | Trends Biochem. Sci. 28:69-74(2003). | |
| PubMed ID | 12575993 |
| 3 | Authors | Chavali G.B. Ekblad C.M. Basu B.P. Brissett N.C. Veprintsev D. Hughes-Davies L. Kouzarides T. Itzhaki L.S. Doherty A.J. |
| Title | Crystal Structure of the ENT Domain of Human EMSY. | |
| Source | J. Mol. Biol. 0:0-0(2005). | |
| PubMed ID | 15978617 | |
| DOI | 10.1016/j.jmb.2005.05.047 |
| 4 | Authors | Ekblad C.M. Chavali G.B. Basu B.P. Freund S.M.V. Veprintsev D. Hughes-Davies L. Kouzarides T. Doherty A.J. Itzhaki L.S. |
| Title | Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. | |
| Source | EMBO Rep. 0:0-0(2005). | |
| PubMed ID | 15947784 | |
| DOI | 10.1038/sj.embor.7400415 |
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