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PROSITE documentation PDOC51165THUMP domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51165
The THUMP (after thiouridine synthases, RNA methylases and pseudouridine synthases) domain is a module of 100-110 amino acid residues which is involved RNA metabolism. It is shared by enzymes that are predicted to carry out at least three unrelated types of RNA-modification, namely methylation, pseudouridylation and thiouridylation. The THUMP domain can occur in stand-alone form or in association with a variety of catalytic domains, like methylase, pseudo U-synthase or rhodanese (see <PDOC00322>). THUMP is an ancient domain with predicted RNA-binding capacity that probably functions by delivering a variety of RNA modification enzymes to their targets. The THUMP domain apparently evolved prior to the divergence of the primary divisions of life [1].
The THUMP domain has been predicted to adopt an α/β fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8 [1].
Some proteins known to contain a THUMP domain are listed below:
- Bacterial and archaeal thiI-like 4-thiouridine synthases.
- Bacterial, archaeal and eukaryotic RNA methylases.
- Archaeal pseudouridine synthases (PSUSs).
- Several uncharacterized proteins.
The profile we developed covers the entire THUMP domain.
Last update:November 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Aravind L. Koonin E.V. |
| Title | THUMP - a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases. | |
| Source | Trends Biochem. Sci. 26:215-217(2001). | |
| PubMed ID | 11295541 |
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