PROSITE documentation PDOC51204
HSA domain profile


The helicase/SANT-associated (HSA) domain is a predicted DNA-binding domain of ~75 amino acids [1], which is found in the eukaryotic SRCAP/p400/DOM and SNF2/brahma families [2]. While each family has the core sequences that define the HSA domain, they each also have additional sequences that distinguish these families from one another. For example, the sequence HWDY(L/C)EEEM(Q/V) is found in the SRCAP/p400/DOM family, whereas the sequence HQE(Y/F)LNSILQ is found in the SNF2 /brahma family [2]. In addition to the SANT and helicase (see <PDOC51192>) domains, the HSA domain is also found in association with bromo (see <PDOC00550>) [1].

Some proteins known to contain a HSA domain are listed below [2]:

  • Yeast transcription regulatory protein SWI2/SNF2.
  • Drosophila brahma.
  • Mammalian SNF2-α (BRM).
  • Mammalian SNF2-β (BRG).
  • Yeast SNF2-related CBP-activating protein (SRCAP), a coactivator for CREB- and nuclear hormone receptor-mediated transcriptional activation.
  • Drosophila domino (DOM), the homolog of SCRAP. It is essential for organismal viability and has been implicated in several aspects of fly development, including hematopoeisis, wing development, and female fertility.
  • Mammalian SRCAP.
  • Mammalian SWI2/SNF2-like ATPase-containing p400/Domino.

The profile we developed covers the entire HSA domain.

Last update:

May 2006 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HSA, PS51204; HSA domain profile  (MATRIX)


1AuthorsDoerks T. Copley R.R. Schultz J. Ponting C.P. Bork P.
TitleSystematic identification of novel protein domain families associated with nuclear functions.
SourceGenome Res. 12:47-56(2002).
PubMed ID11779830

2AuthorsEissenberg J.C. Wong M. Chrivia J.C.
TitleHuman SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.
SourceMol. Cell. Biol. 25:6559-6569(2005).
PubMed ID16024792

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