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PROSITE documentation PDOC51204 |
The helicase/SANT-associated (HSA) domain is a predicted DNA-binding domain of ~75 amino acids [1], which is found in the eukaryotic SRCAP/p400/DOM and SNF2/brahma families [2]. While each family has the core sequences that define the HSA domain, they each also have additional sequences that distinguish these families from one another. For example, the sequence HWDY(L/C)EEEM(Q/V) is found in the SRCAP/p400/DOM family, whereas the sequence HQE(Y/F)LNSILQ is found in the SNF2 /brahma family [2]. In addition to the SANT and helicase (see <PDOC51192>) domains, the HSA domain is also found in association with bromo (see <PDOC00550>) [1].
Some proteins known to contain a HSA domain are listed below [2]:
The profile we developed covers the entire HSA domain.
Last update:May 2006 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Doerks T. Copley R.R. Schultz J. Ponting C.P. Bork P. |
Title | Systematic identification of novel protein domain families associated with nuclear functions. | |
Source | Genome Res. 12:47-56(2002). | |
PubMed ID | 11779830 | |
DOI | 10.1101/ |
2 | Authors | Eissenberg J.C. Wong M. Chrivia J.C. |
Title | Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. | |
Source | Mol. Cell. Biol. 25:6559-6569(2005). | |
PubMed ID | 16024792 | |
DOI | 10.1128/MCB.25.15.6559-6569.2005 |