PROSITE documentation PDOC51225MARVEL domain profile
The ~130-residue MAL and related proteins for vesicle trafficking and membrane link (MARVEL) domain is a module with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families. All described MARVEL domain-containing proteins are consistent with the M-shaped topology: four transmembrane-helix region architecture with cytoplasmic N- and C-terminal regions. Their function could be related to cholesterol-rich membrane apposition events in a variety of cellular processes, such as biogenesis of vesicular transport carriers or tight junction regulation [1].
The profile we developed covers the entire MARVEL domain.
Last update:August 2006 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Sanchez-Pulido L. Martin-Belmonte F. Valencia A. Alonso M.A. |
| Title | MARVEL: a conserved domain involved in membrane apposition events. | |
| Source | Trends Biochem. Sci. 27:599-601(2002). | |
| PubMed ID | 12468223 |
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