PROSITE documentation PDOC51225
MARVEL domain profile


The ~130-residue MAL and related proteins for vesicle trafficking and membrane link (MARVEL) domain is a module with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families. All described MARVEL domain-containing proteins are consistent with the M-shaped topology: four transmembrane-helix region architecture with cytoplasmic N- and C-terminal regions. Their function could be related to cholesterol-rich membrane apposition events in a variety of cellular processes, such as biogenesis of vesicular transport carriers or tight junction regulation [1].

The profile we developed covers the entire MARVEL domain.

Last update:

August 2006 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

MARVEL, PS51225; MARVEL domain profile  (MATRIX)


1AuthorsSanchez-Pulido L. Martin-Belmonte F. Valencia A. Alonso M.A.
TitleMARVEL: a conserved domain involved in membrane apposition events.
SourceTrends Biochem. Sci. 27:599-601(2002).
PubMed ID12468223

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