PROSITE documentation PDOC51271WAPL domain profile
The WINGS APART-LIKE (WAPL) protein of Drosophila melanogaster regulates heterochromatin structure. It is required to hold sister chromatids of meiotic heterochromatin together and is implicated in both heterochromatin pairing during female meiosis and the modulation of position-effect variegation (PEV). Although the high-sequence conservation is limited to a third of the protein sequence, a WAPL homologue has been identified in mammals. Mammalian WAPL may play a significant role in meiosis as does the Drosophila one. Human WAPL is overexpressed in invasive human cervical cancers and is often associated with cervical carcinogenesis [1,2].
The profile we developed covers the entire WAPL domain.
Last update:January 2007 / Profile revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Oikawa K. Ohbayashi T. Kiyono T. Nishi H. Isaka K. Umezawa A. Kuroda M. Mukai K. |
| Title | Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. | |
| Source | Cancer Res. 64:3545-3549(2004). | |
| PubMed ID | 15150110 | |
| DOI | 10.1158/0008-5472.CAN-03-3822 |
| 2 | Authors | Kuroda M. Oikawa K. Ohbayashi T. Yoshida K. Yamada K. Mimura J. Matsuda Y. Fujii-Kuriyama Y. Mukai K. |
| Title | A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis. | |
| Source | FEBS Lett. 579:167-172(2005). | |
| PubMed ID | 15620708 | |
| DOI | 10.1016/j.febslet.2004.11.070 |
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