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PROSITE documentation PDOC51271

WAPL domain profile





Description

The WINGS APART-LIKE (WAPL) protein of Drosophila melanogaster regulates heterochromatin structure. It is required to hold sister chromatids of meiotic heterochromatin together and is implicated in both heterochromatin pairing during female meiosis and the modulation of position-effect variegation (PEV). Although the high-sequence conservation is limited to a third of the protein sequence, a WAPL homologue has been identified in mammals. Mammalian WAPL may play a significant role in meiosis as does the Drosophila one. Human WAPL is overexpressed in invasive human cervical cancers and is often associated with cervical carcinogenesis [1,2].

The profile we developed covers the entire WAPL domain.

Last update:

January 2007 / Profile revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

WAPL, PS51271; WAPL domain profile  (MATRIX)


References

1AuthorsOikawa K. Ohbayashi T. Kiyono T. Nishi H. Isaka K. Umezawa A. Kuroda M. Mukai K.
TitleExpression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression.
SourceCancer Res. 64:3545-3549(2004).
PubMed ID15150110
DOI10.1158/0008-5472.CAN-03-3822

2AuthorsKuroda M. Oikawa K. Ohbayashi T. Yoshida K. Yamada K. Mimura J. Matsuda Y. Fujii-Kuriyama Y. Mukai K.
TitleA dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis.
SourceFEBS Lett. 579:167-172(2005).
PubMed ID15620708
DOI10.1016/j.febslet.2004.11.070



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