PROSITE documentation PDOC51279
Bucentaur C-terminal (BCNT-C) domain profile


Vertebrate BCNT (named after Bucentaur) protein is found in the nucleus and cytosol. Gene duplication of the ancestral BCNT gene leads to the h-type BCNT or craniofacial development protein 1 (CFDP1) gene and the ruminant-specific p97BCNT or craniofacial development protein 2 (CFDP2) gene. The h-type BCNT proteins contain a highly conserved 82-amino acid region at the C-terminus (BCNT-C) that is not present in p97BCNT. Instead ruminant p97BCNT contains a region derived from the endonuclease domain of a retrotransposable element RTE-1 [1,2]. In addition to h-type BCNT proteins, a BCNT-C domain is also found in Drosophila YETI, a protein that binds to a microtubule-based motor kinesin-1, and the yeast SWR1-complex protein 5 (SWC5) or AOR1 (actin overexpression resistant 1), a component of the SWR1 chromatin remodeling complex [2,3].

The profile we developed covers the entire BCNT-C domain.

Last update:

November 2006 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

BCNT_C, PS51279; Bucentaur C-terminal (BCNT-C) domain profile  (MATRIX)


1AuthorsIwashita S. Osada N. Itoh T. Sezaki M. Oshima K. Hashimoto E. Kitagawa-Arita Y. Takahashi I. Masui T. Hashimoto K. Makalowski W.
TitleA transposable element-mediated gene divergence that directly produces a novel type bovine Bcnt protein including the endonuclease domain of RTE-1.
SourceMol. Biol. Evol. 20:1556-1563(2003).
PubMed ID12832649

2AuthorsIwashita S. Ueno S. Nakashima K. Song S.-Y. Ohshima K. Tanaka K. Endo H. Kimura J. Kurohmaru M. Fukuta K. David L. Osada N.
TitleA tandem gene duplication followed by recruitment of a retrotransposon created the paralogous bucentaur gene (bcntp97) in the ancestral ruminant.
SourceMol. Biol. Evol. 23:798-806(2006).
PubMed ID16384818

3AuthorsWisniewski T.P. Tanzi C.L. Gindhart J.G.
TitleThe Drosophila kinesin-I associated protein YETI binds both kinesin subunits.
SourceBiol. Cell 95:595-602(2003).
PubMed ID14720462

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