Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51279Bucentaur C-terminal (BCNT-C) domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51279
Vertebrate BCNT (named after Bucentaur) protein is found in the nucleus and cytosol. Gene duplication of the ancestral BCNT gene leads to the h-type BCNT or craniofacial development protein 1 (CFDP1) gene and the ruminant-specific p97BCNT or craniofacial development protein 2 (CFDP2) gene. The h-type BCNT proteins contain a highly conserved 82-amino acid region at the C-terminus (BCNT-C) that is not present in p97BCNT. Instead ruminant p97BCNT contains a region derived from the endonuclease domain of a retrotransposable element RTE-1 [1,2]. In addition to h-type BCNT proteins, a BCNT-C domain is also found in Drosophila YETI, a protein that binds to a microtubule-based motor kinesin-1, and the yeast SWR1-complex protein 5 (SWC5) or AOR1 (actin overexpression resistant 1), a component of the SWR1 chromatin remodeling complex [2,3].
The profile we developed covers the entire BCNT-C domain.
Last update:November 2006 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Iwashita S. Osada N. Itoh T. Sezaki M. Oshima K. Hashimoto E. Kitagawa-Arita Y. Takahashi I. Masui T. Hashimoto K. Makalowski W. |
| Title | A transposable element-mediated gene divergence that directly produces a novel type bovine Bcnt protein including the endonuclease domain of RTE-1. | |
| Source | Mol. Biol. Evol. 20:1556-1563(2003). | |
| PubMed ID | 12832649 | |
| DOI | 10.1093/molbev/msg168 |
| 2 | Authors | Iwashita S. Ueno S. Nakashima K. Song S.-Y. Ohshima K. Tanaka K. Endo H. Kimura J. Kurohmaru M. Fukuta K. David L. Osada N. |
| Title | A tandem gene duplication followed by recruitment of a retrotransposon created the paralogous bucentaur gene (bcntp97) in the ancestral ruminant. | |
| Source | Mol. Biol. Evol. 23:798-806(2006). | |
| PubMed ID | 16384818 | |
| DOI | 10.1093/molbev/msj088 |
| 3 | Authors | Wisniewski T.P. Tanzi C.L. Gindhart J.G. |
| Title | The Drosophila kinesin-I associated protein YETI binds both kinesin subunits. | |
| Source | Biol. Cell 95:595-602(2003). | |
| PubMed ID | 14720462 |
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