PROSITE documentation PDOC51286RAP domain profile
The ~60-residue RAP (an acronym for RNA-binding domain abundant in Apicomplexans) domain is found in various proteins in eucaryotes. It is particularly abundant in apicomplexans and might mediate a range of cellular functions through its potential interactions with RNA [1].
The RAP domain consists of multiple blocks of charged and aromatics residues and is predicted to be composed of α helical and β strand structures. Two predicted loop regions that are dominated by glycine and tryptophan residues are found before and after the central β sheet [1].
Some proteins known to contain a RAP domain are listed below:
- Human hypothetical protein MGC5297.
- Mammalian FAST kinase domain-containing proteins (FASTKDs).
- Chlamydomonas reinhardtii chloroplastic trans-splicing factor Raa3.
The profile we developed covers the entire RAP domain.
Last update:July 2007 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Lee I. Hong W. |
| Title | RAP-a putative RNA-binding domain. | |
| Source | Trends Biochem. Sci. 29:567-570(2004). | |
| PubMed ID | 15501674 | |
| DOI | 10.1016/j.tibs.2004.09.005 |
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