PROSITE documentation PDOC51286
RAP domain profile


The ~60-residue RAP (an acronym for RNA-binding domain abundant in Apicomplexans) domain is found in various proteins in eucaryotes. It is particularly abundant in apicomplexans and might mediate a range of cellular functions through its potential interactions with RNA [1].

The RAP domain consists of multiple blocks of charged and aromatics residues and is predicted to be composed of α helical and β strand structures. Two predicted loop regions that are dominated by glycine and tryptophan residues are found before and after the central β sheet [1].

Some proteins known to contain a RAP domain are listed below:

  • Human hypothetical protein MGC5297.
  • Mammalian FAST kinase domain-containing proteins (FASTKDs).
  • Chlamydomonas reinhardtii chloroplastic trans-splicing factor Raa3.

The profile we developed covers the entire RAP domain.

Last update:

July 2007 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RAP, PS51286; RAP domain profile  (MATRIX)


1AuthorsLee I. Hong W.
TitleRAP-a putative RNA-binding domain.
SourceTrends Biochem. Sci. 29:567-570(2004).
PubMed ID15501674

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