PROSITE documentation PDOC51290
CRIC domain profile


The multidomain protein Connector enhancer of kinase suppressor of ras (Connector enhancer of KSR) (CNK) functions as a scaffold in several signal cascades and acts on proliferation, differenciation and apoptosis. CNK connects upstream activators and downstream targets of Ras- and Rho-dependent signaling pathways and may allow cross-talks between these pathways. In invertebrates, CNK is expressed as one isoform, whereas in mammals there exists CNK1, CNK2A, and its splice variant CNK2B. CNK proteins consist of one sterile α motif (SAM) domain (see <PDOC50105>), one conserved region in CNK (CRIC) domain, one PSD-96/Dlg-A/ZO-1 (PDZ) domain (see <PDOC50106>), and one pleckstrin homology (PH) domain (see <PDOC50003>). The CRIC domain is enriched in leucine residues and functions as a protein-protein interaction domain [1,2].

The profile we developed covers the entire CRIC domain.

Last update:

January 2007 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CRIC, PS51290; CRIC domain profile  (MATRIX)


1AuthorsIida J. Nishimura W. Yao I. Hata Y.
TitleSynaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain.
SourceEur. J. Neurosci. 15:1493-1498(2002).
PubMed ID12028359

2AuthorsFritz R.D. Radziwill G.
TitleThe scaffold protein CNK1 interacts with the angiotensin II type 2 receptor.
SourceBiochem. Biophys. Res. Commun. 338:1906-1912(2005).
PubMed ID16289034

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