Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51290CRIC domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51290
The multidomain protein Connector enhancer of kinase suppressor of ras (Connector enhancer of KSR) (CNK) functions as a scaffold in several signal cascades and acts on proliferation, differenciation and apoptosis. CNK connects upstream activators and downstream targets of Ras- and Rho-dependent signaling pathways and may allow cross-talks between these pathways. In invertebrates, CNK is expressed as one isoform, whereas in mammals there exists CNK1, CNK2A, and its splice variant CNK2B. CNK proteins consist of one sterile α motif (SAM) domain (see <PDOC50105>), one conserved region in CNK (CRIC) domain, one PSD-96/Dlg-A/ZO-1 (PDZ) domain (see <PDOC50106>), and one pleckstrin homology (PH) domain (see <PDOC50003>). The CRIC domain is enriched in leucine residues and functions as a protein-protein interaction domain [1,2].
The profile we developed covers the entire CRIC domain.
Last update:January 2007 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Iida J. Nishimura W. Yao I. Hata Y. |
| Title | Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain. | |
| Source | Eur. J. Neurosci. 15:1493-1498(2002). | |
| PubMed ID | 12028359 |
| 2 | Authors | Fritz R.D. Radziwill G. |
| Title | The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor. | |
| Source | Biochem. Biophys. Res. Commun. 338:1906-1912(2005). | |
| PubMed ID | 16289034 | |
| DOI | 10.1016/j.bbrc.2005.10.168 |
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