The PET domain is a ~110 amino acid motif in the N-terminal part of LIM domain proteins. The domain was described in Drosophila proteins involved in cell differentiation and is named after Prickle, Espinas and Testin. PET domain proteins contain about three zinc-binding LIM domains (see <PDOC00382>) and are found among metazoans. The PET domain has been suggested to play a role in protein-protein interactions with proteins involved in planar polarity signaling or organisation of the cytoskeleton [1].

Some proteins known to contain a PET domain:

• Mammalian testin protein, which may function as a tumor suppressor.
• Mammalian LIM domain only protein 6 (LMO6).
• Fruit fly prickle and espinas proteins encoded by the tissue polarity gene prickle (pk), involved in the control of orientation of bristles and hairs.
• Mammalian prickle-like proteins 1 and 2.

The profile we developed covers the entire PET domain.