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PROSITE documentation PDOC51328 |
The carbohydrate recognition domain (CRD) of the following proteins shares a striking structural similarity with calcium-dependent L-type (leguminous) lectins:
The L-type lectin-like domain has an overall globular shape composed of a β-sandwich of two major twisted antiparallel β-sheets (see <PDB:1GV9>). The β-sandwich comprises a major concave β-sheet and a minor convex β-sheet, in a variation of the jelly roll fold [1,2,3,4].
The profile we developed covers the entire L-type lectin-like domain.
Last update:August 2007 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Velloso L.M. Svensson K. Schneider G. Pettersson R.F. Lindqvist Y. |
Title | Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum. | |
Source | J. Biol. Chem. 277:15979-15984(2002). | |
PubMed ID | 11850423 | |
DOI | 10.1074/jbc.M112098200 |
2 | Authors | Velloso L.M. Svensson K. Pettersson R.F. Lindqvist Y. |
Title | The crystal structure of the carbohydrate-recognition domain of the glycoprotein sorting receptor p58/ERGIC-53 reveals an unpredicted metal-binding site and conformational changes associated with calcium ion binding. | |
Source | J. Mol. Biol. 334:845-851(2003). | |
PubMed ID | 14643651 |
3 | Authors | Satoh T. Sato K. Kanoh A. Yamashita K. Yamada Y. Igarashi N. Kato R. Nakano A. Wakatsuki S. |
Title | Structures of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47p. | |
Source | J. Biol. Chem. 281:10410-10419(2006). | |
PubMed ID | 16439369 | |
DOI | 10.1074/jbc.M512258200 |
4 | Authors | Satoh T. Cowieson N.P. Hakamata W. Ideo H. Fukushima K. Kurihara M. Kato R. Yamashita K. Wakatsuki S. |
Title | Structural basis for recognition of high-mannose type glycoproteins by mammalian transport lectin VIP36. | |
Source | J. Biol. Chem. 0:0-0(2007). | |
PubMed ID | 17652092 | |
DOI | 10.1074/jbc.M703064200 |