PROSITE documentation PDOC51328L-type lectin-like (leguminous) domain profile
Description
The carbohydrate recognition domain (CRD) of the following proteins shares a striking structural similarity with calcium-dependent L-type (leguminous) lectins:
- Yeast proteins EMP46 and EMP47, type I membrane proteins, which cycle between the endoplasmic reticulum (ER) and the Golgi apparatus by vesicles coated with coat protein complexes I and II (COPI and COPII). They are considered to function as cargo reveptors for exporting N-linked glycoproteins from the ER.
- Animal p58/ERGIC-53, a calcium-dependent lectin that cycles between the endoplasmic reticulum (ER) and the Golgi complex and appears to act as a cargo receptor for a subset of soluble glycoproteins exported from the ER.
- Mammalian vesicular-integral protein of 36 kDa (VIP36), a transport lectin for trafficking certain high-mannose type glycoproteins in the early secretory pathway.
The L-type lectin-like domain has an overall globular shape composed of a β-sandwich of two major twisted antiparallel β-sheets (see <PDB:1GV9>). The β-sandwich comprises a major concave β-sheet and a minor convex β-sheet, in a variation of the jelly roll fold [1,2,3,4].
The profile we developed covers the entire L-type lectin-like domain.
Last update:August 2007 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Velloso L.M. Svensson K. Schneider G. Pettersson R.F. Lindqvist Y. |
| Title | Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum. | |
| Source | J. Biol. Chem. 277:15979-15984(2002). | |
| PubMed ID | 11850423 | |
| DOI | 10.1074/jbc.M112098200 |
| 2 | Authors | Velloso L.M. Svensson K. Pettersson R.F. Lindqvist Y. |
| Title | The crystal structure of the carbohydrate-recognition domain of the glycoprotein sorting receptor p58/ERGIC-53 reveals an unpredicted metal-binding site and conformational changes associated with calcium ion binding. | |
| Source | J. Mol. Biol. 334:845-851(2003). | |
| PubMed ID | 14643651 |
| 3 | Authors | Satoh T. Sato K. Kanoh A. Yamashita K. Yamada Y. Igarashi N. Kato R. Nakano A. Wakatsuki S. |
| Title | Structures of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47p. | |
| Source | J. Biol. Chem. 281:10410-10419(2006). | |
| PubMed ID | 16439369 | |
| DOI | 10.1074/jbc.M512258200 |
| 4 | Authors | Satoh T. Cowieson N.P. Hakamata W. Ideo H. Fukushima K. Kurihara M. Kato R. Yamashita K. Wakatsuki S. |
| Title | Structural basis for recognition of high-mannose type glycoproteins by mammalian transport lectin VIP36. | |
| Source | J. Biol. Chem. 0:0-0(2007). | |
| PubMed ID | 17652092 | |
| DOI | 10.1074/jbc.M703064200 |
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