We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51328L-type lectin-like (leguminous) domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51328
Description
The carbohydrate recognition domain (CRD) of the following proteins shares a striking structural similarity with calcium-dependent L-type (leguminous) lectins:
- Yeast proteins EMP46 and EMP47, type I membrane proteins, which cycle between the endoplasmic reticulum (ER) and the Golgi apparatus by vesicles coated with coat protein complexes I and II (COPI and COPII). They are considered to function as cargo reveptors for exporting N-linked glycoproteins from the ER.
- Animal p58/ERGIC-53, a calcium-dependent lectin that cycles between the endoplasmic reticulum (ER) and the Golgi complex and appears to act as a cargo receptor for a subset of soluble glycoproteins exported from the ER.
- Mammalian vesicular-integral protein of 36 kDa (VIP36), a transport lectin for trafficking certain high-mannose type glycoproteins in the early secretory pathway.
The L-type lectin-like domain has an overall globular shape composed of a β-sandwich of two major twisted antiparallel β-sheets (see <PDB:1GV9>). The β-sandwich comprises a major concave β-sheet and a minor convex β-sheet, in a variation of the jelly roll fold [1,2,3,4].
The profile we developed covers the entire L-type lectin-like domain.
Last update:August 2007 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Velloso L.M. Svensson K. Schneider G. Pettersson R.F. Lindqvist Y. |
| Title | Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum. | |
| Source | J. Biol. Chem. 277:15979-15984(2002). | |
| PubMed ID | 11850423 | |
| DOI | 10.1074/jbc.M112098200 |
| 2 | Authors | Velloso L.M. Svensson K. Pettersson R.F. Lindqvist Y. |
| Title | The crystal structure of the carbohydrate-recognition domain of the glycoprotein sorting receptor p58/ERGIC-53 reveals an unpredicted metal-binding site and conformational changes associated with calcium ion binding. | |
| Source | J. Mol. Biol. 334:845-851(2003). | |
| PubMed ID | 14643651 |
| 3 | Authors | Satoh T. Sato K. Kanoh A. Yamashita K. Yamada Y. Igarashi N. Kato R. Nakano A. Wakatsuki S. |
| Title | Structures of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47p. | |
| Source | J. Biol. Chem. 281:10410-10419(2006). | |
| PubMed ID | 16439369 | |
| DOI | 10.1074/jbc.M512258200 |
| 4 | Authors | Satoh T. Cowieson N.P. Hakamata W. Ideo H. Fukushima K. Kurihara M. Kato R. Yamashita K. Wakatsuki S. |
| Title | Structural basis for recognition of high-mannose type glycoproteins by mammalian transport lectin VIP36. | |
| Source | J. Biol. Chem. 0:0-0(2007). | |
| PubMed ID | 17652092 | |
| DOI | 10.1074/jbc.M703064200 |
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