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PROSITE documentation PDOC51382 |
Hydrophilic and poorly conserved SPX (SYG1, Pho81 and XPR11) domains, of about 180 residues, are found at the N-termini of various proteins, particularly signal transduction proteins. There are proteins harboring the SPX domain in all major eukaryotic kingdoms. SPX domains are composed of three subdomains, which are separated by two areas of low similarity. They are often (1) variable in sequence, (2) split due to insertions, or (3) fragmented due to deletions. The tripartite SPX domain could function as a sensor for inorganic phosphate (Pi) level and is most likely a domain for protein interaction. Possibly all SPX domains bind G-protein β-subunits for the purpose of signal transduction [1,2,3].
Some proteins known to contain a SPX domain are listed below:
The profile we developed covers the entire SPX domain.
Last update:May 2008 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Barabote R.D. Tamang D.G. Abeywardena S.N. Fallah N.S. Fu J.Y.C. Lio J.K. Mirhosseini P. Pezeshk R. Podell S. Salampessy M.L. Thever M.D. Saier M.H. Jr. |
Title | Extra domains in secondary transport carriers and channel proteins. | |
Source | Biochim. Biophys. Acta 1758:1557-1579(2006). | |
PubMed ID | 16905115 | |
DOI | 10.1016/j.bbamem.2006.06.018 |
2 | Authors | Duan K. Yi K. Dang L. Huang H. Wu W. Wu P. |
Title | Characterization of a sub-family of Arabidopsis genes with the SPX domain reveals their diverse functions in plant tolerance to phosphorus starvation. | |
Source | Plant. J. 0:0-0(2008). | |
PubMed ID | 18315545 | |
DOI | 10.1111/j.1365-313X.2008.03460.x |
3 | Authors | Wang Y. Secco D. Poirier Y. |
Title | Characterization of the PHO1 gene family and the responses to phosphate deficiency of Physcomitrella patens. | |
Source | Plant. Physiol. 146:646-656(2008). | |
PubMed ID | 18055586 | |
DOI | 10.1104/pp.107.108548 |