PROSITE documentation PDOC51398PAW domain profile
The PAW domain (present in PNGases and other worm proteins) is found as a single copy at the C-terminus of metazoan peptide:N-glycanase (PNGase) and in multiple copies in hypothetical Caenorhabditis elegans proteins peptide:N-glycanases (PNGases) [1]. The C-terminal PAW domain of PNGase binds to the mannose moieties of N-linked oligosaccharide chains [2].
The PAW domain is a slightly elongated molecule and displays a β-sandwich architecture, which is composed of two layers, containing nine and eight antiparallel β-strands, respectively, and three additional short helices (see <PDB:2G9G>) [2].
Some proteins known to contain a PAW domain are listed below:
- Animal peptide:N-glycanase (PNGase) (EC 3.5.1.52), catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving the bulky glycan chain before the proteins are degraded by the proteasome.
- Caenorhabditis elegans putative uncharacterized protein C17B7.5.
The profile we developed covers the entire PAW domain.
Last update:July 2008 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Doerks T. Copley R.R. Schultz J. Ponting C.P. Bork P. |
| Title | Systematic identification of novel protein domain families associated with nuclear functions. | |
| Source | Genome Res. 12:47-56(2002). | |
| PubMed ID | 11779830 | |
| DOI | 10.1101/ |
| 2 | Authors | Zhou X. Zhao G. Truglio J.J. Wang L. Li G. Lennarz W.J. Schindelin H. |
| Title | Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 103:17214-17219(2006). | |
| PubMed ID | 17088551 | |
| DOI | 10.1073/pnas.0602954103 |
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