PROSITE documentation PDOC51414HSR domain profile
The following proteins share a nuclear dot (DT) targeting and dimerization domain of ~100 amino acids [1,2,3]:
- Mammalian nuclear autoantigen Sp-100, a constituent of nuclear domains known as nuclear dots (NDs) or promyelocytic leukemia (PML) bodies. It may play a role in the control of gene expression.
- Murine Sp100-rs, a murine-truncated Sp-100 homologue, which is expressed from a highly amplified gene. In some mice strains, the amplification has progressed to such extremely high copy numbers that the amplified gene locus is visible as a homogeneously staining region (HSR) on the corresponding murine chromosome.
- Mammalian nuclear body protein SP140-like or LySp100B protein.
- Mammalian Sp110 nuclear body protein.
- Vertebrate AutoImmune REgulator (AIRE) protein, a transcription regulator predominantly expressed in thymus medullary epithelial cells. It subcellularly localizes to nuclear dots.
As this domain comprises most of the sequence of the truncated murine Sp100-rs protein, it was termed HSR domain [2]. The HSR domain, which has also been named ASS (AIRE, Sp-100 and Sp140) domain [3], can also be found N-terminally in association with other domains, such as SAND (see <PDOC50864>), PHD finger (see <PDOC50016>) and Bromo (see <PDOC00550>), The HSR domain is predicted to be predominantly α-helical [1,2,3].
The profile we developed covers the entire HSR domain.
Last update:December 2008 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Gibson T.J. Ramu C. Gemuend C. Aasland R. |
| Title | The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor. | |
| Source | Trends Biochem. Sci. 23:242-244(1998). | |
| PubMed ID | 9697411 |
| 2 | Authors | Sternsdorf T. Jensen K. Reich B. Will H. |
| Title | The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers. | |
| Source | J. Biol. Chem. 274:12555-12566(1999). | |
| PubMed ID | 10212234 |
| 3 | Authors | Mittaz L. Rossier C. Heino M. Peterson P. Krohn K.J.E. Gos A. Morris M.A. Kudoh J. Shimizu N. Antonarakis S.E. Scott H.S. |
| Title | Isolation and characterization of the mouse Aire gene. | |
| Source | Biochem. Biophys. Res. Commun. 255:483-490(1999). | |
| PubMed ID | 10049735 | |
| DOI | 10.1006/bbrc.1999.0223 |
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