PROSITE documentation PDOC51439
MENTAL domain profile


The following proteins share a conserved region called the MENTAL (MLN64 N-terminal) domain composed of four transmembrane helices with three short intervening loops [1,2,3]:

  • Animal MLN64 (metastatic lymph node 64), a late endosomal membrane protein containing a carboxyl-terminal cholesterol binding START domain (see <PDOC50848>). It is probably involved in intracellular cholesterol transport.
  • Mammalian MENTHO (MLN64 N-terminal domain homologue), a late endosomal protein containing only the MENTAL domain. It is probably involved in cellular cholesterol homoeostasis.

The ~170-amino acid MENTAL domain mediates MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol. The MENTAL domain might serve to maintain cholesterol at the membrane of late endosomes prior to its shuttle to cytoplasmic acceptor(s) through the START domain.

The profile we developed covers the entire MENTAL domain.

Last update:

March 2009 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

MENTAL, PS51439; MENTAL domain profile  (MATRIX)


1AuthorsAlpy F. Wendling C. Rio M.-C. Tomasetto C.
TitleMENTHO, a MLN64 homologue devoid of the START domain.
SourceJ. Biol. Chem. 277:50780-50787(2002).
PubMed ID12393907

2AuthorsAlpy F. Latchumanan V.K. Kedinger V. Janoshazi A. Thiele C. Wendling C. Rio M.-C. Tomasetto C.
TitleFunctional characterization of the MENTAL domain.
SourceJ. Biol. Chem. 280:17945-17952(2005).
PubMed ID15718238

3AuthorsAlpy F. Tomasetto C.
TitleMLN64 and MENTHO, two mediators of endosomal cholesterol transport.
SourceBiochem. Soc. Trans. 34:343-345(2006).
PubMed ID16709157

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