PROSITE documentation PDOC51447Ferredoxin-fold anticodon binding (FDX-ACB) domain profile
Aminoacyl-tRNA synthetases (aaRSs) play a crucial role in the translation of the genetic code by means of covalent attachment of amino acids to their cognate tRNAs. Phenylalanine--tRNA synthetase (PheRS) is known to be among the most complex enzymes of the aaRS family. Bacterial and mitochondrial PheRSs share a ferredoxin-fold anticodon binding (FDX-ACB) domain, which represents a canonical double split α+β motif having no insertions. The FDX-ACB domain displays a typical RNA recognition fold (RRM) (see <PDOC00030>) formed by the four-stranded antiparallel β sheet, with two helices packed against it (see <PDB:3CMQ>) [1,2,3,4,5].
The profile we developed covers the entire FDX-ACB domain.
Last update:April 2009 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Mosyak L. Reshetnikova L. Goldgur Y. Delarue M. Safro M.G. |
| Title | Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus. | |
| Source | Nat. Struct. Biol. 2:537-547(1995). | |
| PubMed ID | 7664121 |
| 2 | Authors | Goldgur Y. Mosyak L. Reshetnikova L. Ankilova V. Lavrik O. Khodyreva S. Safro M. |
| Title | The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe. | |
| Source | Structure 5:59-68(1997). | |
| PubMed ID | 9016717 |
| 3 | Authors | Rodova M. Ankilova V. Safro M.G. |
| Title | Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. | |
| Source | Biochem. Biophys. Res. Commun. 255:765-773(1999). | |
| PubMed ID | 10049785 | |
| DOI | 10.1006/bbrc.1999.0141 |
| 4 | Authors | Moor N. Lavrik O. Favre A. Safro M. |
| Title | Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end. | |
| Source | Biochemistry 42:10697-10708(2003). | |
| PubMed ID | 12962494 | |
| DOI | 10.1021/bi034732q |
| 5 | Authors | Klipcan L. Levin I. Kessler N. Moor N. Finarov I. Safro M. |
| Title | The tRNA-induced conformational activation of human mitochondrial phenylalanyl-tRNA synthetase. | |
| Source | Structure 16:1095-1104(2008). | |
| PubMed ID | 18611382 | |
| DOI | 10.1016/j.str.2008.03.020 |
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