Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51447Ferredoxin-fold anticodon binding (FDX-ACB) domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51447
Aminoacyl-tRNA synthetases (aaRSs) play a crucial role in the translation of the genetic code by means of covalent attachment of amino acids to their cognate tRNAs. Phenylalanine--tRNA synthetase (PheRS) is known to be among the most complex enzymes of the aaRS family. Bacterial and mitochondrial PheRSs share a ferredoxin-fold anticodon binding (FDX-ACB) domain, which represents a canonical double split α+β motif having no insertions. The FDX-ACB domain displays a typical RNA recognition fold (RRM) (see <PDOC00030>) formed by the four-stranded antiparallel β sheet, with two helices packed against it (see <PDB:3CMQ>) [1,2,3,4,5].
The profile we developed covers the entire FDX-ACB domain.
Last update:April 2009 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Mosyak L. Reshetnikova L. Goldgur Y. Delarue M. Safro M.G. |
| Title | Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus. | |
| Source | Nat. Struct. Biol. 2:537-547(1995). | |
| PubMed ID | 7664121 |
| 2 | Authors | Goldgur Y. Mosyak L. Reshetnikova L. Ankilova V. Lavrik O. Khodyreva S. Safro M. |
| Title | The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe. | |
| Source | Structure 5:59-68(1997). | |
| PubMed ID | 9016717 |
| 3 | Authors | Rodova M. Ankilova V. Safro M.G. |
| Title | Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. | |
| Source | Biochem. Biophys. Res. Commun. 255:765-773(1999). | |
| PubMed ID | 10049785 | |
| DOI | 10.1006/bbrc.1999.0141 |
| 4 | Authors | Moor N. Lavrik O. Favre A. Safro M. |
| Title | Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end. | |
| Source | Biochemistry 42:10697-10708(2003). | |
| PubMed ID | 12962494 | |
| DOI | 10.1021/bi034732q |
| 5 | Authors | Klipcan L. Levin I. Kessler N. Moor N. Finarov I. Safro M. |
| Title | The tRNA-induced conformational activation of human mitochondrial phenylalanyl-tRNA synthetase. | |
| Source | Structure 16:1095-1104(2008). | |
| PubMed ID | 18611382 | |
| DOI | 10.1016/j.str.2008.03.020 |
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