PROSITE documentation PDOC51508
CKK domain profile


The C-terminal CKK domain is common to CAMSAP1 (calmodulin-regulated spectrin-associated protein 1), KIAA1078 (CAMSAP2), and KIAA1543 (CAMSAP3). The CAMSAP family represents a novel class of microtubule-binding protein. It is defined by a unique architecture, namely, a CH-like domain (see <PDOC50021>) near the N-terminus and the CKK domain at the C-terminus. The strong conservation of the sequence of the CKK domain suggests that its fold is conserved in all eumetazoan. The structure of the CKK domain is a β barrel with an associated α helical hairpin (see <PDB:1UGJ>). Characteristically, the CKK domain has a single invariant Trp within the core of the predicted β-barrel. Residues that interact with this Trp to form part of this core are highly conserved too. The CKK domain binds microtubules [1].

The profile we developed covers the entire CKK domain.

Last update:

August 2010 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CKK, PS51508; CKK domain profile  (MATRIX)


1AuthorsBaines A.J. Bignone P.A. King M.D.A. Maggs A.M. Bennett P.M. Pinder J.C. Phillips G.W.
TitleThe CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins.
SourceMol. Biol. Evol. 26:2005-2014(2009).
PubMed ID19508979

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