PROSITE documentation PDOC51508CKK domain profile
The C-terminal CKK domain is common to CAMSAP1 (calmodulin-regulated spectrin-associated protein 1), KIAA1078 (CAMSAP2), and KIAA1543 (CAMSAP3). The CAMSAP family represents a novel class of microtubule-binding protein. It is defined by a unique architecture, namely, a CH-like domain (see <PDOC50021>) near the N-terminus and the CKK domain at the C-terminus. The strong conservation of the sequence of the CKK domain suggests that its fold is conserved in all eumetazoan. The structure of the CKK domain is a β barrel with an associated α helical hairpin (see <PDB:1UGJ>). Characteristically, the CKK domain has a single invariant Trp within the core of the predicted β-barrel. Residues that interact with this Trp to form part of this core are highly conserved too. The CKK domain binds microtubules [1].
The profile we developed covers the entire CKK domain.
Last update:August 2010 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Baines A.J. Bignone P.A. King M.D.A. Maggs A.M. Bennett P.M. Pinder J.C. Phillips G.W. |
| Title | The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins. | |
| Source | Mol. Biol. Evol. 26:2005-2014(2009). | |
| PubMed ID | 19508979 | |
| DOI | 10.1093/molbev/msp115 |
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