Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51508CKK domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51508
The C-terminal CKK domain is common to CAMSAP1 (calmodulin-regulated spectrin-associated protein 1), KIAA1078 (CAMSAP2), and KIAA1543 (CAMSAP3). The CAMSAP family represents a novel class of microtubule-binding protein. It is defined by a unique architecture, namely, a CH-like domain (see <PDOC50021>) near the N-terminus and the CKK domain at the C-terminus. The strong conservation of the sequence of the CKK domain suggests that its fold is conserved in all eumetazoan. The structure of the CKK domain is a β barrel with an associated α helical hairpin (see <PDB:1UGJ>). Characteristically, the CKK domain has a single invariant Trp within the core of the predicted β-barrel. Residues that interact with this Trp to form part of this core are highly conserved too. The CKK domain binds microtubules [1].
The profile we developed covers the entire CKK domain.
Last update:August 2010 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Baines A.J. Bignone P.A. King M.D.A. Maggs A.M. Bennett P.M. Pinder J.C. Phillips G.W. |
| Title | The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins. | |
| Source | Mol. Biol. Evol. 26:2005-2014(2009). | |
| PubMed ID | 19508979 | |
| DOI | 10.1093/molbev/msp115 |
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