PROSITE documentation PDOC51515Bin3-type S-adenosyl-L-methionine (SAM) domain profile
Description
The Bin3 domain contains a tripartite S-adenosyl-L-methionine (SAM) binding motif with all three sequence motifs, I/Ia, II, and III [1]. It is found in the following proteins:
- Drosophila melanogaster probable methyltransferase Bin3 (EC 2.1.1.-). It interacts with bicoid/bcd.
- Human 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) or Bicoid-interacting protein 3 homolog (Bin3 homolog), a S-adenosyl-L- methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.
- Caenorhabditis elegans probable methyltransferase Y17G7B.18 (EC 2.1.1.-).
The profile we developed covers the entire Bin3-type SAM domain.
Last update:December 2010 / First entry.
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Technical section
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Reference
| 1 | Authors | Zhu W. Hanes S.D. |
| Title | Identification of drosophila bicoid-interacting proteins using a custom two-hybrid selection. | |
| Source | Gene 245:329-339(2000). | |
| PubMed ID | 10717484 |
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