PROSITE documentation PDOC51515
Bin3-type S-adenosyl-L-methionine (SAM) domain profile


The Bin3 domain contains a tripartite S-adenosyl-L-methionine (SAM) binding motif with all three sequence motifs, I/Ia, II, and III [1]. It is found in the following proteins:

  • Drosophila melanogaster probable methyltransferase Bin3 (EC 2.1.1.-). It interacts with bicoid/bcd.
  • Human 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) or Bicoid-interacting protein 3 homolog (Bin3 homolog), a S-adenosyl-L- methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.
  • Caenorhabditis elegans probable methyltransferase Y17G7B.18 (EC 2.1.1.-).

The profile we developed covers the entire Bin3-type SAM domain.

Last update:

December 2010 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

BIN3_SAM, PS51515; Bin3-type S-adenosyl-L-methionine (SAM) domain profile  (MATRIX)


1AuthorsZhu W. Hanes S.D.
TitleIdentification of drosophila bicoid-interacting proteins using a custom two-hybrid selection.
SourceGene 245:329-339(2000).
PubMed ID10717484

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