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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE documentation PDOC51515
Bin3-type S-adenosyl-L-methionine (SAM) domain profile


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PURL: https://purl.expasy.org/prosite/documentation/PDOC51515

Description

The Bin3 domain contains a tripartite S-adenosyl-L-methionine (SAM) binding motif with all three sequence motifs, I/Ia, II, and III [1]. It is found in the following proteins:

  • Drosophila melanogaster probable methyltransferase Bin3 (EC 2.1.1.-). It interacts with bicoid/bcd.
  • Human 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) or Bicoid-interacting protein 3 homolog (Bin3 homolog), a S-adenosyl-L- methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.
  • Caenorhabditis elegans probable methyltransferase Y17G7B.18 (EC 2.1.1.-).

The profile we developed covers the entire Bin3-type SAM domain.

Last update:

December 2010 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

BIN3_SAM, PS51515; Bin3-type S-adenosyl-L-methionine (SAM) domain profile  (MATRIX)


Reference

1AuthorsZhu W. Hanes S.D.
TitleIdentification of drosophila bicoid-interacting proteins using a custom two-hybrid selection.
SourceGene 245:329-339(2000).
PubMed ID10717484



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