We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51664YcaO domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51664
Description
The YcaO domain is found in the following proteins:
- Escherichia YcaO, involved in β-methylthiolation of ribosomal protein S12 [1].
- Bacterial and archeal thiazole/oxazole-modified microcin (TOMM) D protein, which uses ATP to activate amide backbones during peptide cyclodehydrations [2].
The YcaO domain is likely to be involved in post-translational modification (PTM) of amino acid residues.
The profile we developed covers the entire YcaO domain.
Last update:January 2013 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Strader M.B. Costantino N. Elkins C.A. Chen C.Y. Patel I. Makusky A.J. Choy J.S. Court D.L. Markey S.P. Kowalak J.A. |
| Title | A proteomic and transcriptomic approach reveals new insight into beta-methylthiolation of Escherichia coli ribosomal protein S12. Mol. Cell. Proteomics 10:M110.005199-M110.005199(2011). | |
| PubMed ID | 21169565 | |
| DOI | 10.1074/mcp.M110.005199 |
| 2 | Authors | Dunbar K.L. Melby J.O. Mitchell D.A. |
| Title | YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. | |
| Source | Nat. Chem. Biol. 8:569-575(2012). | |
| PubMed ID | 22522320 | |
| DOI | 10.1038/nchembio.944 |
Copyright
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