PROSITE documentation PDOC51664YcaO domain profile
Description
The YcaO domain is found in the following proteins:
- Escherichia YcaO, involved in β-methylthiolation of ribosomal protein S12 [1].
- Bacterial and archeal thiazole/oxazole-modified microcin (TOMM) D protein, which uses ATP to activate amide backbones during peptide cyclodehydrations [2].
The YcaO domain is likely to be involved in post-translational modification (PTM) of amino acid residues.
The profile we developed covers the entire YcaO domain.
Last update:January 2013 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Strader M.B. Costantino N. Elkins C.A. Chen C.Y. Patel I. Makusky A.J. Choy J.S. Court D.L. Markey S.P. Kowalak J.A. |
| Title | A proteomic and transcriptomic approach reveals new insight into beta-methylthiolation of Escherichia coli ribosomal protein S12. Mol. Cell. Proteomics 10:M110.005199-M110.005199(2011). | |
| PubMed ID | 21169565 | |
| DOI | 10.1074/mcp.M110.005199 |
| 2 | Authors | Dunbar K.L. Melby J.O. Mitchell D.A. |
| Title | YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. | |
| Source | Nat. Chem. Biol. 8:569-575(2012). | |
| PubMed ID | 22522320 | |
| DOI | 10.1038/nchembio.944 |
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