PROSITE documentation PDOC51697ALOG domain profile
The 125-residue ALOG (Arabidopsis LSH1 and oryza G1) domain is rich in basic amino acids, especially arginine, and is highly conserved among land plants. Members of the ALOG family of proteins function as key developmental regulators. It has been proposed that the ALOG domain originated from the N-terminal DNA-binding domains of integrases belonging to the tyrosine recombinase superfamily encoded by a distinct type of DIRS1-like LTR retrotransposon found in several eukaryotes. Secondary structure predictions revealed an all-α helical domain with four conserved helices [1,2].
Some proteins known to contain an ALOG domain are listed below:
- Arabidopsis thaliana LIGHT_DEPENDENT SHORT HYPOCOTYLS1 (LSH1), involved in phytochrome-dependent light signaling.
- Oryza G1, involved in the specification of sterile lemma identity.
- Plant defence proteins.
The profile we developed covers the entire ALOG domain.
Last update:December 2013 / First entry.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Yoshida A. Suzaki T. Tanaka W. Hirano H.-Y. |
| Title | The homeotic gene long sterile lemma (G1) specifies sterile lemma identity in the rice spikelet. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 106:20103-20108(2009). | |
| PubMed ID | 19901325 | |
| DOI | 10.1073/pnas.0907896106 |
| 2 | Authors | Iyer L.M. Aravind L. |
| Title | ALOG domains: provenance of plant homeotic and developmental regulators from the DNA-binding domain of a novel class of DIRS1-type retroposons. | |
| Source | Biol. Direct 7:39-39(2012). | |
| PubMed ID | 23146749 | |
| DOI | 10.1186/1745-6150-7-39 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)