PROSITE documentation PDOC51738
Peptidase family C21 domain profile


The family Tymoviridae comprises the genus Tymovirus, from which it derives its name, the genus Marafivirus and the genus Maculavirus [1,E1]. Members of the family are plant viruses that have the following traits in common: icosahedral virion structure, a monopartite single-stranded RNA genome with a very high cytidine content and a similar genome organization. The replication strategy encompasses post-translational proteolytic cleavage of the polypeptide encoded by ORF1 by a peptidase family C21 domain [E2]. The peptidase family C21 domain is a papain-like proteinase with catalytic cysteine and histidine residues [2,3].

Some proteins known to contain a peptidase family C21 domain are listed below:

  • Turnip yellow mosaic virus (TYMV) replication-associated polyprotein (RP).
  • Grapevine fleck virus (GFkV) replication-associated polyprotein (RP).
  • Oat blue dwarf virus (OBDV) replication-associated polyprotein (RP).
  • Maize rayado fino virus (MRFV) replication-associated polyprotein (RP).
  • Olive latent virus 3 (OLV-3) replication-associated polyprotein (RP).
  • Eggplant mosaic virus (EMV) replication-associated polyprotein (RP).
  • Ononis yellow mosaic virus (OYMV) replication-associated polyprotein (RP).
  • Kennedya yellow mosaic virus (KYMV) replication-associated polyprotein (RP).
  • Erysimum latent virus (ELV) replication-associated polyprotein (RP).

The profile we developed covers the entire peptidase family C21 domain.

Last update:

November 2014 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PEPTIDASE_C21, PS51738; Peptidase family C21 domain profile  (MATRIX)


1AuthorsMartelli G.P. Sabanadzovic S. Abou-Ghanem Sabanadzovic N. Edwards M.C. Dreher T.
TitleThe family Tymoviridae.
SourceArch. Virol. 147:1837-1846(2002).
PubMed ID12209322

2AuthorsBransom K.L. Dreher T.W.
TitleIdentification of the essential cysteine and histidine residues of the turnip yellow mosaic virus protease.
SourceVirology 198:148-154(1994).
PubMed ID8037790

3AuthorsAlabdullah A. Minafra A. Elbeaino T. Saponari M. Savino V. Martelli G.P.
TitleComplete nucleotide sequence and genome organization of Olive latent virus 3, a new putative member of the family Tymoviridae.
SourceVirus Res. 152:10-18(2010).
PubMed ID20561953



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