PROSITE logo

PROSITE documentation PDOC51738
Peptidase family C21 domain profile


Description

The family Tymoviridae comprises the genus Tymovirus, from which it derives its name, the genus Marafivirus and the genus Maculavirus [1,E1]. Members of the family are plant viruses that have the following traits in common: icosahedral virion structure, a monopartite single-stranded RNA genome with a very high cytidine content and a similar genome organization. The replication strategy encompasses post-translational proteolytic cleavage of the polypeptide encoded by ORF1 by a peptidase family C21 domain [E2]. The peptidase family C21 domain is a papain-like proteinase with catalytic cysteine and histidine residues [2,3].

Some proteins known to contain a peptidase family C21 domain are listed below:

  • Turnip yellow mosaic virus (TYMV) replication-associated polyprotein (RP).
  • Grapevine fleck virus (GFkV) replication-associated polyprotein (RP).
  • Oat blue dwarf virus (OBDV) replication-associated polyprotein (RP).
  • Maize rayado fino virus (MRFV) replication-associated polyprotein (RP).
  • Olive latent virus 3 (OLV-3) replication-associated polyprotein (RP).
  • Eggplant mosaic virus (EMV) replication-associated polyprotein (RP).
  • Ononis yellow mosaic virus (OYMV) replication-associated polyprotein (RP).
  • Kennedya yellow mosaic virus (KYMV) replication-associated polyprotein (RP).
  • Erysimum latent virus (ELV) replication-associated polyprotein (RP).

The profile we developed covers the entire peptidase family C21 domain.

Last update:

November 2014 / First entry.

-------------------------------------------------------------------------------


Technical section

PROSITE method (with tools and information) covered by this documentation:

PEPTIDASE_C21, PS51738; Peptidase family C21 domain profile  (MATRIX)


References

1AuthorsMartelli G.P. Sabanadzovic S. Abou-Ghanem Sabanadzovic N. Edwards M.C. Dreher T.
TitleThe family Tymoviridae.
SourceArch. Virol. 147:1837-1846(2002).
PubMed ID12209322
DOI10.1007/s007050200045

2AuthorsBransom K.L. Dreher T.W.
TitleIdentification of the essential cysteine and histidine residues of the turnip yellow mosaic virus protease.
SourceVirology 198:148-154(1994).
PubMed ID8037790
DOI10.1006/viro.1994.1017

3AuthorsAlabdullah A. Minafra A. Elbeaino T. Saponari M. Savino V. Martelli G.P.
TitleComplete nucleotide sequence and genome organization of Olive latent virus 3, a new putative member of the family Tymoviridae.
SourceVirus Res. 152:10-18(2010).
PubMed ID20561953
DOI10.1016/j.virusres.2010.05.010

E1Titlehttps://viralzone.expasy.org/54?outline=all_by_protein

E2Titlehttps://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c21



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)