The SpoVT-AbrB domain is a DNA-binding domain found in a large protein superfamily [1,2], which includes:

• Bacterial antibiotic resistance protein B (AbrB), a transition-state regulator.
• Bacterial SpoVT, a late sporulation factor that modulates forespore- specific sigma G-dependent transcription.
• Bacterial PrlF, an antitoxin component of a toxin-antitoxin (TA) module.
• Bacterial transcription factors (antitoxins) of plasmid maintenance systems (VapB, MvpT, VppA ,VagC, PemI, MazE, ChpS).
• Bacterial transcriptional regulator MraZ, involved in the expression of the division and cell wall (dcw) cluster. It contains two copies of the SpoVT- AbrB domain.
• Bacterial endoribonuclease SymE.
• Sulfolobus solfataricus repressor-like proteins SSo7c3 and SSo7c4.

The SpoVT-AbrB domain contains four β strands and one α helix and can be described as a pair of β hairpins linked by the α helix (see <PDB:1YSF>) [1,2].

The profile we developed covers the entire SpoVT-AbrB domain.