We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51740SpoVT-AbrB domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51740
Description
The SpoVT-AbrB domain is a DNA-binding domain found in a large protein superfamily [1,2], which includes:
- Bacterial antibiotic resistance protein B (AbrB), a transition-state regulator.
- Bacterial SpoVT, a late sporulation factor that modulates forespore- specific sigma G-dependent transcription.
- Bacterial PrlF, an antitoxin component of a toxin-antitoxin (TA) module.
- Bacterial transcription factors (antitoxins) of plasmid maintenance systems (VapB, MvpT, VppA ,VagC, PemI, MazE, ChpS).
- Bacterial transcriptional regulator MraZ, involved in the expression of the division and cell wall (dcw) cluster. It contains two copies of the SpoVT- AbrB domain.
- Bacterial endoribonuclease SymE.
- Sulfolobus solfataricus repressor-like proteins SSo7c3 and SSo7c4.
The SpoVT-AbrB domain contains four β strands and one α helix and can be described as a pair of β hairpins linked by the α helix (see <PDB:1YSF>) [1,2].
The profile we developed covers the entire SpoVT-AbrB domain.
Last update:December 2014 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Bobay B.G. Andreeva A. Mueller G.A. Cavanagh J. Murzin A.G. |
| Title | Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. | |
| Source | FEBS Lett. 579:5669-5674(2005). | |
| PubMed ID | 16223496 | |
| DOI | 10.1016/j.febslet.2005.09.045 |
| 2 | Authors | Coles M. Djuranovic S. Soeding J. Frickey T. Koretke K. Truffault V. Martin J. Lupas A.N. |
| Title | AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels. | |
| Source | Structure 13:919-928(2005). | |
| PubMed ID | 15939023 | |
| DOI | 10.1016/j.str.2005.03.017 |
Copyright
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