|PROSITE documentation PDOC51795|
Zinc fingers are a ubiquitous class of protein domain with considerable variation in structure and function. The FCS-type zinc finger is a highly diverged group of C2-C2 zinc finger which is present in animals, prokaryotes and viruses, but not in plant. It is named after the conserved phenylalanine and serine residues associated with the third cysteine. The FCS-type zinc finger is a structurally diverse family which accommodate both nucleic-protein and protein-protein interaction zinc fingers. The FCS-Like Zinc finger (FLZ) domain is a plant specific domain found in all taxa except algae. FLZ domain containing proteins are bryophytic in origin and this protein family is expanded in higher plants. Although the molecular functions of the FLZ protein family members in general are not well understood, many of the members are attributed to plant growth and development, stress mitigation, sugar signaling and senescence. The FLZ-type zinc finger is likely to be involved in protein-protein interaction [1,2,3].
The FLZ-type zinc finger is predicted to form an α-β-α secondary structure composed of an N-terminal short α-helix, a β hairpin followed by a longer C-terminal α helix. Four highly conserved cysteine residues in the FLZ-type zinc finger are believed to bind zinc in a tetrahedral coordination [1,2].
Some proteins known to contain a FLZ-type zinc finger are listed below :
The profile we developed covers the entire FLZ-type zinc finger.Last update:
March 2016 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||He Y. Gan S.|
|Title||A novel zinc-finger protein with a proline-rich domain mediates ABA-regulated seed dormancy in Arabidopsis.|
|Source||Plant Mol. Biol. 54:1-9(2004).|
|2||Authors||K M.J. Laxmi A.|
|Title||DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.|
|Source||PLoS ONE 9:E99074-E99074(2014).|
|3||Authors||Jamsheer K M. Mannully C.T. Gopan N. Laxmi A.|
|Title||Comprehensive Evolutionary and Expression Analysis of FCS-Like Zinc finger Gene Family Yields Insights into Their Origin, Expansion and Divergence.|
|Source||PLoS ONE 10:E0134328-E0134328(2015).|
|4||Authors||Jamsheer K M. Laxmi A.|
|Title||Expression of Arabidopsis FCS-Like Zinc finger genes is differentially regulated by sugars, cellular energy level, and abiotic stress.|
|Source||Front. Plant Sci. 6:746-746(2015).|