PROSITE documentation PDOC51820
PA14 domain profile


The ~150-amino acid PA14 domain, named after its location in the protective antigen of anthrax toxin, is found in a variety of bacterial and eukaryotic proteins such as glycosidases, glycosyltransferases, proteases, amidases, toxins, adhesins and signaling molecules. The PA14 domain is combined in a mosaic manner with various catalytic or non-catalytic domains directly or indirectly implicated in binding carbohydrate or peptidoglycan. It could be a carbohydrate-binding module [1,2,3].

The PA14 domain is a β-barrel structure comprising two β-sheets (see <PDB:1ACC>). The N and C termini of the domain are close together in space, presumably, thereby facilitating the insertion of the PA14 domain into other recognized domains without structural disruption [1,2,3].

The profile we developed covers the entire PA14 domain.

Last update:

November 2016 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PA14, PS51820; PA14 domain profile  (MATRIX)


1AuthorsRigden D.J. Mello L.V. Galperin M.Y.
TitleThe PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules.
SourceTrends Biochem. Sci. 29:335-339(2004).
PubMed ID15236739

2AuthorsYoshida E. Hidaka M. Fushinobu S. Koyanagi T. Minami H. Tamaki H. Kitaoka M. Katayama T. Kumagai H.
TitleRole of a PA14 domain in determining substrate specificity of a glycoside hydrolase family 3 beta-glucosidase from Kluyveromyces marxianus.
SourceBiochem. J. 431:39-49(2010).
PubMed ID20662765

3AuthorsPetosa C. Collier R.J. Klimpel K.R. Leppla S.H. Liddington R.C.
TitleCrystal structure of the anthrax toxin protective antigen.
SourceNature 385:833-838(1997).
PubMed ID9039918

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