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PROSITE documentation PDOC51825

DIPSY domain profile





Description

In fungi, cell adhesion is required for flocculation, mating and virulence, and it is mediated by covalently bound cell wall proteins termed adhesins, which include flocculins and mating agglutinins. Several members of the Mam3/ Map4 adhesin family possess a variety of conserved domains at their C-termini. One of these, the DIPSY (Asp-Ile-Pro-Ser-Tyr) domain appears to be specific to the genus Schizosaccharomyces. Four S. pombe proteins as well as one S. japonicus protein contain DIPSY domains:

  • Fission yeast mating-type specific agglutinin Map4.
  • Fission yeast putative cell agglutination protein pfl3 (SPBC947.04).
  • Fission yeast putative cell-type specific agglutination protein pfl7 (SPBC359.04c).
  • Fission yeast putative cell agglutination protein pfl9 (SPAC186.01).
  • Schizosaccharomyces japonicus cell agglutination protein mam3 (SJAG_04723).

The DIPSY domain is a functional adhesion domain [1,2].

The profile we developed covers the entire DIPSY domain.

Last update:

December 2016 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

DIPSY, PS51825; DIPSY domain profile  (MATRIX)


References

1AuthorsLinder T. Gustafsson C.M.
TitleMolecular phylogenetics of ascomycotal adhesins--a novel family of putative cell-surface adhesive proteins in fission yeasts.
SourceFungal Genet. Biol. 45:485-497(2008).
PubMed ID17870620
DOI10.1016/j.fgb.2007.08.002

2AuthorsSharifmoghadam M.R. Valdivieso M.-H.
TitleThe Schizosaccharomyces pombe Map4 adhesin is a glycoprotein that can be extracted from the cell wall with alkali but not with beta-glucanases and requires the C-terminal DIPSY domain for function.
SourceMol. Microbiol. 69:1476-1490(2008).
PubMed ID18673459
DOI10.1111/j.1365-2958.2008.06375.x



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