PROSITE documentation PDOC52010Collectrin-like domain profile
The transmembrane protease angiotensin converting enzyme 2 (ACE2) is a protective regulator within the renin angiotensin system and additionally represents the cellular receptor for SARS-CoVs. It functions as carboxypeptidase and cleaves the C-terminal amino acid of angiotensin I to angiotensin 1-9 or directly converts angiotensin II to angiotensin 1-7. ACE2 consists of an N-terminal catalytically active metalloprotease domain and a C-terminal collectrin-like domain [1,2,3]. Collectrin is a type I membrane protein and shares significant homology with the C-terminal domain of ACE2. However, collectrin lacks catalytic domain and it suggests the presence of uncharacterized physiological functions of collectrin. Collectrin binds to SNARE complex protein such as snapin and the collectrin-mediated processes of vesicle transport and fusion to the plasma membrane in a polarized manner is crucial for delivering insulin and amino acid transporters [4,5].
The collectrin-like domain mediates homodimerization. It consists of a small extracellular neck subdomain, which adopts a ferredoxin-like fold, a long linker, and a single transmembrane (TM) helix (see <PDB:6M18>) [1].
The profile we developed covers the entire collectrin-like domain.
Last update:October 2022 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Yan R. Zhang Y. Li Y. Xia L. Guo Y. Zhou Q. |
| Title | Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. | |
| Source | Science 367:1444-1448(2020). | |
| PubMed ID | 32132184 | |
| DOI | 10.1126/science.abb2762 |
| 2 | Authors | Wiese O. Zemlin A.E. Pillay T.S. |
| Title | Molecules in pathogenesis: angiotensin converting enzyme 2 (ACE2). | |
| Source | J. Clin. Pathol. 74:285-290(2021). | |
| PubMed ID | 32759311 | |
| DOI | 10.1136/jclinpath-2020-206954 |
| 3 | Authors | Niehues R.V. Wozniak J. Wiersch F. Lilienthal E. Tacken N. Schumertl T. Garbers C. Ludwig A. Duesterhoeft S. |
| Title | The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17. | |
| Source | FASEB. J. 36:E22234-E22234(2022). | |
| PubMed ID | 35199397 | |
| DOI | 10.1096/fj.202101521R |
| 4 | Authors | Zhang Y. Wada J. |
| Title | Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives. | |
| Source | Biochem. Biophys. Res. Commun. 363:1-5(2007). | |
| PubMed ID | 17825789 | |
| DOI | 10.1016/j.bbrc.2007.08.136 |
| 5 | Authors | Chu P.-L. Le T.H. |
| Title | Role of collectrin, an ACE2 homologue, in blood pressure homeostasis. | |
| Source | Curr. Hypertens. Rep. 16:490-490(2014). | |
| PubMed ID | 25182162 | |
| DOI | 10.1007/s11906-014-0490-4 |
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