PROSITE documentation PDOC52032MarR-like, BRCT and chromo domains module profile
Mammalian SWI/SNF (mSWI/SNF) of BAF complexes are a subfamily of SWI/SNF ATP-dependent chromatin remodelers that dynamically modulate chromatin structure to regulate fundamental cellular processes including gene transcription, cell cycle control, and DNA damage response [1]. The BAF155/SMARCC1 subunit is a component of all complexes identified to date, incorporated either as a homodimer or as a heterodimer with its paralog BAF170/SMARCC2. The BAF155 subunit predominates in stem cells, while the BAF170 subunit is incorporated during differentiation. The N-terminus of the BAF155/SMARCC1 and BAF170/ SMARCC2 subunits contain a putative DNA-binding MarR-like domain, a chromo domain (see <PDOC00517>) and a BRCT domain that are interconnected to each other to form a distinct module. This N-terminal module could participate in an interaction involving both protein and nucleic acid components [2].
The MarR-like domain forms a four-helix-bundle that resembles the MarR-like helix-turn-helix domain (see <PDOC00861>). The BRCT domain contains an inserted chromo domain between the second and third strands of the canonical fold. The chromo domain consists of the curved antiparallel three-stranded β-sheet characteristic of this domain. The individual domains are linked via a network of hydrogen bonds to form a single structural unit (see <PDB:6YXO>. The architecture of the fold produces a cleft containing two deep pockets at the interface between the domains [2].
The profile we developed covers the entire MarR-like, BRCT and chromo domains module.
Last update:July 2023 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Yan L. Xie S. Du Y. Qian C. |
| Title | Structural Insights into BAF47 and BAF155 Complex Formation. | |
| Source | J. Mol. Biol. 429:1650-1660(2017). | |
| PubMed ID | 28438634 | |
| DOI | 10.1016/j.jmb.2017.04.008 |
| 2 | Authors | Allen M.D. Freund S.M.V. Bycroft M. Zinzalla G. |
| Title | SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site. | |
| Source | Commun. Biol. 4:528-528(2021). | |
| PubMed ID | 33953332 | |
| DOI | 10.1038/s42003-021-02050-z |
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