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PROSITE documentation PDOC60029

Spider toxin CSTX family signature





Description

Spider toxins of the CSTX family are ion channel toxins containing an inhibitor cystine knot (ICK) structural motif or Knottin scaffold (see <PDOC60004>) [E1]. The four disulfide bonds present in the CSTX spider toxin family are arranged in the following pattern: 1-4, 2-5, 3-8 and 6-7.

This family includes:

  • Cupiennius salei (Wandering spider) toxin CSTX-1 and its proteolytic products CSTX-2a and CSTX-2b [1].
  • Cupiennius salei (Wandering spider) CSTX-9 [2].
  • Cupiennius salei (Wandering spider) CSTX-13, a neurotoxic enhancer. In contrast to CSTX-1 and CSTX-9, CSTX-13 is a two-chain peptide with two interchain and two intrachain disulfide bridges [3].

We have developed a pattern that contains the six conserved cysteines with a cysteine arrangement C-C-CC-C-C which are also found in the A chain of CSTX-13.

Expert(s) to contact by email:

Ramakumar S.

Last update:

February 2006 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

SPIDER_CSTX, PS60029; Spider toxin CSTX family signature  (PATTERN)


References

1AuthorsKuhn-Nentwig L. Schaller J. Kaempfer U. Imboden H. Malli H. Nentwig W.
TitleA lysine rich C-terminal tail is directly involved in the toxicity of CSTX-1, a neurotoxic peptide from the venom of the spider Cupiennius salei.
SourceArch. Insect Biochem. Physiol. 44:101-111(2000).
PubMed ID10897091
DOI10.1002/1520-6327(200007)44:3<101::AID-ARCH1>3.0.CO;2-S

2AuthorsSchaller J. Kaempfer U. Schuerch S. Kuhn-Nentwig L. Haeberli S. Nentwig W.
TitleCSTX-9, a toxic peptide from the spider Cupiennius salei: amino acid sequence, disulphide bridge pattern and comparison with other spider toxins containing the cystine knot structure.
SourceCell. Mol. Life Sci. 58:1538-1545(2001).
PubMed ID11693532

3AuthorsWullschleger B. Kuhn-Nentwig L. Tromp J. Kaempfer U. Schaller J. Schuerch S. Nentwig W.
TitleCSTX-13, a highly synergistically acting two-chain neurotoxic enhancer in the venom of the spider Cupiennius salei (Ctenidae).
SourceProc. Natl. Acad. Sci. U.S.A. 101:11251-11256(2004).
PubMed ID15272079
DOI10.1073/pnas.0402226101

E1Sourcehttp://knottin.cbs.cnrs.fr



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