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PROSITE entry PS00014


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00014
Entry name [info] ER_TARGET
Accession [info] PS00014
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00014

Name and characterization of the entry

Description [info] Endoplasmic reticulum targeting sequence.
Pattern [info] 
[KRHQSA]-[DENQ]-E-L>.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 574 in 574 different sequences
Number of true positive hits 370 in 370 different sequences
Number of 'unknown' hits 8 in 8 different sequences
Number of false positive hits 196 in 196 different sequences
Number of false negative sequences 18
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 65.37 %
Recall (true positives / (true positives + false negatives)) 95.36 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Feature key [info] MOTIF
Feature description [info] Prevent secretion from ER (Potential)
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 370 sequences 

1106L_ASFB7 (P68744), 1106L_ASFK5 (P0C9H8), 1106L_ASFM2 (P0C9H9),
» more

UniProtKB/Swiss-Prot
False negative sequences		 18 sequences 

BIP2_ORYSJ  (Q53RJ5), CALR3_BOVIN (Q2TBR8), CALR3_MOUSE (Q9D9Q6),
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 8 sequences 

CUE1_CANAL  (Q59NY7), FDFT_NEUCR  (Q7S4Z6), GPX8A_XENLA (Q6IRC8),
» more

UniProtKB/Swiss-Prot
False positive sequences		 196 sequences 

1106L_ASFL5 (P68745), AARD_PROST  (Q52402), ABCA6_MOUSE (Q8K441),
» more

PDB
[Detailed view]		 54 PDB

1G7D; 1OVN; 1XMB; 2B5E; 2C0F; 2C0G; 2C1Y; 2DIZ; 2FCW; 2FTU; 2IY9; 2M66;
» more