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PROSITE entry PS00019


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PURL: https://purl.expasy.org/prosite/signature/PS00019

Direct ScanProsite submission
General information about the entry

Entry name [info] ACTININ_1
Accession [info] PS00019
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00019

Name and characterization of the entry

Description [info] Actinin-type actin-binding domain signature 1.
Pattern [info] 
[EQ]-{LNYH}-x-[ATV]-[FY]-{LDAM}-{T}-W-{PG}-N.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 124 in 111 different sequences
Number of true positive hits 100 in 87 different sequences
Number of 'unknown' hits 0
Number of false positive hits 24 in 24 different sequences
Number of false negative sequences 5
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 80.65 %
Recall (true positives / (true positives + false negatives)) 95.24 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 87 sequences 

ACTN1_BOVIN (Q3B7N2), ACTN1_CHICK (P05094), ACTN1_HUMAN (P12814), 

ACTN1_MACFA (Q2PFV7), ACTN1_MOUSE (Q7TPR4), ACTN1_RAT   (Q9Z1P2), 
ACTN2_BOVIN (Q3ZC55), ACTN2_CHICK (P20111), ACTN2_HUMAN (P35609), 
ACTN2_MOUSE (Q9JI91), ACTN3_BOVIN (Q0III9), ACTN3_HUMAN (Q08043), 
ACTN3_MOUSE (O88990), ACTN4_BOVIN (A5D7D1), ACTN4_CHICK (Q90734), 
ACTN4_HUMAN (O43707), ACTN4_MOUSE (P57780), ACTN4_PONAB (Q5RCS6), 
ACTN4_RAT   (Q9QXQ0), ACTNA_DICDI (P05095), ACTNB_DICDI (O76329), 
ACTN_ANOGA  (Q7PKQ5), ACTN_DERFA  (L7UZ85), ACTN_DROME  (P18091), 
ANC1_CAEEL  (Q9N4M4), CLMN_HUMAN  (Q96JQ2), CLMN_MOUSE  (Q8C5W0), 
CTXA_DICDI  (Q54HG2), CTXA_HETP5  (Q9Y0T4), CTXB_DICDI  (Q550R2), 
DMDA_DROME  (Q9VDW6), DMD_CAEEL   (Q9TW65), DMD_CANLF   (O97592), 
DMD_CHICK   (P11533), DMD_HUMAN   (P11532), DMD_MOUSE   (P11531), 
DMD_PIG (Q5GN48), DMD_RAT (P11530), DYST_HUMAN  (Q03001), 
DYST_MOUSE  (Q91ZU6), FIMB2_ARATH (O50064), FIMB_DICDI  (P54680), 
FIMB_SCHPO  (O59945), FIMB_YEAST  (P32599), FLNA_DROME  (Q9VEN1), 
FLNA_HUMAN  (P21333), FLNA_MOUSE  (Q8BTM8), FLNB_HUMAN  (O75369), 
FLNB_MOUSE  (Q80X90), FLNC_HUMAN  (Q14315), FLNC_MOUSE  (Q8VHX6), 
FLNC_RAT(D3ZHA0), GELA_DICDI  (P13466), MACF1_HUMAN (Q9UPN3), 
MACF1_MOUSE (Q9QXZ0), MACF1_RAT   (D3ZHV2), MS300_DROME (M9MRD1), 
PLEC_HUMAN  (Q15149), PLEC_MOUSE  (Q9QXS1), PLSI_BOVIN  (A6H742), 
PLSI_CHICK  (P19179), PLSI_HUMAN  (Q14651), PLSI_MOUSE  (Q3V0K9), 
PLSL_DANRE  (Q6P698), PLSL_HUMAN  (P13796), PLSL_MOUSE  (Q61233), 
PLST_BOVIN  (A7E3Q8), PLST_CRIGR  (O88818), PLST_DANRE  (Q6DG81), 
PLST_HUMAN  (P13797), PLST_MOUSE  (Q99K51), PLST_RAT(Q63598), 
SPTB1_HUMAN (P11277), SPTB1_MOUSE (P15508), SPTB2_HUMAN (Q01082), 
SPTB2_MOUSE (Q62261), SPTCB_DROME (Q00963), SPTN2_HUMAN (O15020), 
SPTN2_RAT   (Q9QWN8), SPTN4_HUMAN (Q9H254), SPTN5_HUMAN (Q9NRC6), 
SYNE1_HUMAN (Q8NF91), SYNE1_MOUSE (Q6ZWR6), SYNE2_HUMAN (Q8WXH0), 
SYNE2_MOUSE (Q6ZWQ0), UTRN_HUMAN  (P46939), UTRN_RAT(G3V7L1)
» more

UniProtKB/Swiss-Prot
False negative sequences		 5 sequences 

AIN1_SCHPO  (O13728), FIMB1_ARATH (Q7G188), FIMB3_ARATH (Q9FJ70), 

FIMB5_ARATH (Q9FKI0), PLEC_RAT(P30427)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

PLEC_CRIGR  (Q9JI55)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			24 sequences
			


			
CARDB_CYNCA (Q9XFX4), CAS3_PECAS  (Q6D0W9), CATA_MICLU  (P29422), 

			
CELA1_HUMAN (Q9UNI1), CEP1_VZVD   (P09301), CRH2_ASPFU  (Q4WI46), 
CSLG1_ARATH (Q570S7), CSLG2_ARATH (Q8VYR4), CSLG3_ARATH (Q0WVN5), 
CYPR1_CYNCA (P40782), EDSBC_ARATH (Q9SU71), F8H1_OCIBA  (A0A076FFM5), 
F8H2_OCIBA  (A0A076FF10), FT105_SCHPO (O13776), INT1_HUMAN  (Q8N201), 
INT1_MOUSE  (Q6P4S8), MTMR7_MOUSE (Q9Z2C9), NRPS4_GIBZE (I1RF49), 
OPSB_ASPOR  (Q8NKB6), RDRP_OCSVU  (Q83927), RNA14_SCHPO (O14233), 
SEPF_CLOD6  (Q182V6), STAB2_MOUSE (Q8R4U0), ZDHC7_DICDI (Q552M6)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			45 PDB
			


			pdb_00001aoa; pdb_00001dxx; pdb_00001mb8; pdb_00001qag; pdb_00001rt8; pdb_00001sh5; pdb_00001sh6; pdb_00001sjj; pdb_00001tjt; pdb_00001wku; pdb_00002eyi; pdb_00002eyn; 
			
				pdb_00002r0o; pdb_00002wa5; pdb_00002wa6; pdb_00002wa7; pdb_00002wfn; pdb_00003f7p; pdb_00003fer; pdb_00003hoc; pdb_00003hop; pdb_00003hor; pdb_00003lue; pdb_00004b7l; 
				pdb_00004d1e; pdb_00004q57; pdb_00004q58; pdb_00004q59; pdb_00004z6g; pdb_00005a36; pdb_00005a37; pdb_00005a38; pdb_00005a4b; pdb_00006anu; pdb_00006d8c; pdb_00006m5g; 
				pdb_00006o31; pdb_00006oa6; pdb_00006swt; pdb_00006vec; pdb_00007r94; pdb_00007sx8; pdb_00007sx9; pdb_00007sxa; pdb_00009d58
			
			

			» more